公开(公告)号：US20100291134A1

公开(公告)日：2010-11-18

申请号：US12847312

申请日：2010-07-30

申请人： Michael Houghton ,  Angelica Medina-Selby ,  Doris Coit

发明人： Michael Houghton ,  Angelica Medina-Selby ,  Doris Coit

IPC分类号： A61K39/29 ,  C07K2/00 ,  C07K14/00 ,  A61K38/00 ,  C07H21/04 ,  C12N15/79 ,  C12N5/10 ,  C12P21/00 ,  A61P37/04 ,  A61P31/14

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/53 ,  C07K2319/40 ,  C12N2770/24222

摘要： The invention provides truncated HCV NS5 polypeptides and fusion proteins comprising the truncated NS5 polypeptides, fused to at least one other HCV epitope derived from another region of the HCV polyprotein. The fusions can be used in methods of stimulating an immune response to HCV, for example a cellular immune response to HCV, such as activating hepatitis C virus (HCV)-specific T cells, including CD4+ and CD8+ T cells. The method can be used in model systems to develop HCV-specific immunogenic compositions, as well as to immunize a mammal against HCV.

摘要翻译： 本发明提供了截短的HCV NS5多肽和包含截短的NS5多肽的融合蛋白，其融合至至少一种源自HCV多蛋白的另一区域的其它HCV表位。 融合物可以用于刺激对HCV的免疫应答的方法，例如对HCV的细胞免疫应答，例如激活丙型肝炎病毒（HCV）特异性T细胞，包括CD4 +和CD8 + T细胞。 该方法可以在模型系统中用于开发HCV特异性免疫原性组合物，以及免疫哺乳动物抗HCV。

公开(公告)号：US20100047271A1

公开(公告)日：2010-02-25

申请号：US12612992

申请日：2009-11-05

申请人： Debbi Drane ,  John Cox ,  Michael Houghton ,  Xavier Pallard

发明人： Debbi Drane ,  John Cox ,  Michael Houghton ,  Xavier Pallard

IPC分类号： A61K39/29 ,  A61P31/12

CPC分类号： A61K39/29 ,  A61K39/12 ,  A61K2039/55544 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/57 ,  C12N2770/24234

摘要： The present invention relates generally to an immunogenic complex comprising a charged organic carrier and a charged antigen and, more particularly, a negatively charged organic carrier and a positively charged antigen, wherein the charged antigen is a polyprotein of Hepatitis C Virus (HCV), particularly the core protein of HCV, or a fragment thereof, or a fusion protein comprising the polyprotein or a fragment thereof. The complexes of the present invention are useful, inter alia, in vaccine compositions as therapeutic and/or prophylactic agents for facilitating the induction of immune responses, and in particular a cytotoxic T-lymphocyte response, in the treatment of a disease condition which results from an HCV infection.

摘要翻译： 本发明一般涉及包含带电荷的有机载体和带​​电荷的抗原的免疫原性复合物，更具体地，涉及带负电荷的有机载体和带​​正电荷的抗原，其中带电的抗原是丙型肝炎病毒（HCV）的多蛋白，特别是 HCV的核心蛋白或其片段，或包含该多聚蛋白或其片段的融合蛋白。 本发明的复合物尤其可用于疫苗组合物中，作为促进免疫应答诱导的治疗和/或预防剂，特别是细胞毒性T淋巴细胞应答，用于治疗由 HCV感染。

公开(公告)号：US20090324604A1

公开(公告)日：2009-12-31

申请号：US10585459

申请日：2005-01-06

申请人： Cheng Liu ,  Deborah Lee Zimmerman ,  Gregory M. Harrowe ,  Kirston Koths ,  William M. Kavanaugh ,  Li Long ,  Arnold Horwitz ,  Maria Calderon-Cacia

发明人： Cheng Liu ,  Deborah Lee Zimmerman ,  Gregory M. Harrowe ,  Kirston Koths ,  William M. Kavanaugh ,  Li Long ,  Arnold Horwitz ,  Maria Calderon-Cacia

IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P35/00 ,  A61P19/00

CPC分类号： C07K16/243 ,  A61K31/663 ,  A61K31/675 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： M-CSF-specific antibody RX1 is provided, along with pharmaceutical compositions containing antibody RX1, kits containing a pharmaceutical composition, and methods of preventing and treating bone loss in a subject afflicted with an osteolytic disease.

摘要翻译： 提供了M-CSF特异性抗体RX1，以及含有抗体RX1的药物组合物，含有药物组合物的试剂盒，以及预防和治疗患有溶骨性疾病的受试者的骨丢失的方法。

公开(公告)号：US20090226995A1

公开(公告)日：2009-09-10

申请号：US11929633

申请日：2007-10-30

申请人： Giulia C. Kennedy

发明人： Giulia C. Kennedy

IPC分类号： C12N9/96 ,  C07K7/00 ,  C07K14/00

CPC分类号： C07K14/47

摘要： The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia.

公开(公告)号：US20090142350A1

公开(公告)日：2009-06-04

申请号：US11929748

申请日：2007-10-30

申请人： Giulia C. Kennedy

发明人： Giulia C. Kennedy

IPC分类号： A61K39/395 ,  C07K16/18

CPC分类号： C07K14/47

摘要： The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia.

公开(公告)号：US20090060912A1

公开(公告)日：2009-03-05

申请号：US12188984

申请日：2008-08-08

申请人： John N. Nuss ,  Sabina Pecchi ,  Paul A. Renhowe

发明人： John N. Nuss ,  Sabina Pecchi ,  Paul A. Renhowe

IPC分类号： A61K31/5377 ,  C07D413/14 ,  A61K31/551 ,  A61P35/00 ,  A61K39/395 ,  C07D243/08

CPC分类号： C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： Compounds having formula I are provided where the variables have the values described herein. Pharmaceutical formulations include the compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and combinations with other agents. A method of treating a patient comprises administering a pharmaceutical formulation according to the invention to a patient in need thereof.

摘要翻译： 提供具有式I的化合物，其中变量具有本文所述的值。 药物制剂包括其化合物或其药学上可接受的盐和药学上可接受的载体以及与其它药剂的组合。 治疗患者的方法包括向有需要的患者施用根据本发明的药物制剂。

公开(公告)号：US20090036321A1

公开(公告)日：2009-02-05

申请号：US10559480

申请日：2004-06-03

申请人： Edward Moler ,  Filippo Randazzo ,  Michael Rowe

发明人： Edward Moler ,  Filippo Randazzo ,  Michael Rowe

IPC分类号： C40B30/04 ,  C12Q1/02 ,  G01N33/574 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136

摘要： The present invention relates to methods of predicting the course of malignant disease and more specifically to methods which use SERPINE2 as a prognostic indicator of disease in cancer patients.

摘要翻译： 本发明涉及预测恶性疾病进程的方法，更具体地涉及使用SERPINE2作为癌症患者疾病预后指标的方法。

公开(公告)号：US20080293624A1

公开(公告)日：2008-11-27

申请号：US09944930

申请日：2001-08-31

申请人： Robert V. Hageman ,  Bret A. Shirley ,  Kamaljit K. Bajwa

发明人： Robert V. Hageman ,  Bret A. Shirley ,  Kamaljit K. Bajwa

IPC分类号： A61K38/18

CPC分类号： A61K47/183 ,  A61K9/0019 ,  A61K38/1825 ,  A61K47/18 ,  A61K47/26

摘要： Stabilized FGF compositions are provided. The compositions comprise FGF or variant thereof and at least one reducing agent in an amount sufficient to inhibit FGF oxidation. Methods for increasing stability of FGF or variant thereof in a liquid or lyophilized composition and for increasing storage stability of such a composition are also provided.

摘要翻译： 提供稳定的FGF组合物。 组合物包含FGF或其变体和至少一种足以抑制FGF氧化的还原剂。 还提供了用于提高液体或冻干组合物中FGF或其变体的稳定性和增加这种组合物的储存稳定性的方法。

公开(公告)号：US20080286279A1

公开(公告)日：2008-11-20

申请号：US10593135

申请日：2005-03-17

申请人： Abla Creasey

发明人： Abla Creasey

IPC分类号： A61K39/395 ,  A61K38/16 ,  A61K31/727

CPC分类号： A61K38/57 ,  A61K38/00

摘要： Methods for prophylactically or therapeutically treating severe pneumonia involve administration of tissue factor pathway inhibitor (TFPI) or a TFPI analog to patients suffering from or at risk of developing this condition. The methods involve the use of continuous intravenous infusion of TFPI or a TFPI analog, preferably at low doses to avoid adverse side effects.

摘要翻译： 用于预防或治疗重症肺炎的方法涉及组织因子途径抑制剂（TFPI）或TFPI类似物给患有或有发展该病症风险的患者。 所述方法包括使用连续静脉内输注TFPI或TFPI类似物，优选低剂量以避免不良副作用。

公开(公告)号：US20080274111A1

公开(公告)日：2008-11-06

申请号：US11929965

申请日：2007-10-30

申请人： Giulia C. Kennedy

发明人： Giulia C. Kennedy

IPC分类号： A61K39/395 ,  C07K16/32

CPC分类号： C07K14/47

摘要： The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia.