发明授权
- 专利标题: Process for the microbiological preparation of human serum albumin
- 专利标题(中): 人血清白蛋白微生物制备工艺
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申请号: US843725申请日: 1986-03-25
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公开(公告)号: US4914027A公开(公告)日: 1990-04-03
- 发明人: Michael Knapp , Georges Brefort , Martine Latta , Jean-Francois Mayaux , Paolo Sarmientos
- 申请人: Michael Knapp , Georges Brefort , Martine Latta , Jean-Francois Mayaux , Paolo Sarmientos
- 申请人地址: FRX Joinville Le Pont
- 专利权人: Genetica
- 当前专利权人: Genetica
- 当前专利权人地址: FRX Joinville Le Pont
- 优先权: FRX8504385 19850325
- 主分类号: C12N15/09
- IPC分类号: C12N15/09 ; A61K35/74 ; A61K38/16 ; C07K14/765 ; C12N9/84 ; C12N15/70
摘要:
Human serum albumin is produced by culturing a bacterium (e.g. E. coli) capable of maintaining a plasmid containing an inducible promoter (e.g. P.sub.trp) upstream of the penicillin amidase promoter, the ribosome binding site of the penicillin amidase gene and the penicillin amidase signal peptide, fused with the structural gene for human serum albumin.
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