发明授权
US4923858A Substituted 3-(n-heterocyclic)-2,6-diaminopyridines and -n-oxides
失效
取代的3-(正 - 杂环)-2,6-二氨基吡啶和 - 氧化物
- 专利标题: Substituted 3-(n-heterocyclic)-2,6-diaminopyridines and -n-oxides
- 专利标题(中): 取代的3-(正 - 杂环)-2,6-二氨基吡啶和 - 氧化物
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申请号: US352287申请日: 1989-05-16
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公开(公告)号: US4923858A公开(公告)日: 1990-05-08
- 发明人: Jurgen Engel , Peter Emig , Bernd Nickel , Istvan Szelenyi
- 申请人: Jurgen Engel , Peter Emig , Bernd Nickel , Istvan Szelenyi
- 申请人地址: DEX Frankfurt am Main
- 专利权人: Asta Pharma Aktiengesellschaft
- 当前专利权人: Asta Pharma Aktiengesellschaft
- 当前专利权人地址: DEX Frankfurt am Main
- 优先权: DEX3816629 19880516
- 主分类号: A61K31/44
- IPC分类号: A61K31/44 ; A61K31/535 ; A61P25/04 ; A61P25/08 ; A61P29/00 ; C07D401/04 ; C07D413/04 ; C07D417/04
摘要:
Compounds of the general formula: ##STR1## wherein the radicals R.sub.1 and R.sub.2 are the same or different and represent hydrogen or C.sub.1 -C.sub.6 -alkyl, the radicals R.sub.3 and R.sub.4 are the same or different and represent hydrogen, C.sub.1 -C.sub.6 -alkyl, hydroxy, C.sub.1 -C.sub.6 -alkoxy, C.sub.2 -C.sub.6 -alkanoyloxy, halogen or C.sub.2 -C.sub.6 -alkanoyl, X is oxygen, sulphur or the group --NR.sub.5 and R.sub.5 is hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkanoyl or benzoyl, m and n in each case may represent the integers 1, 2 or 3 and the phenyl radical A is unsubsituted or is substituted by halogen, nitro, C.sub.1 -C.sub.6 -alkyl, trifluoromethyl, C.sub.3 -C.sub.7 -cycloalkyl, hydroxy, C.sub.1 -C.sub.6 -alkoxy, C.sub.2 -C.sub.6 -alkanoyloxy, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, C.sub.2 -C.sub.6 -alkanoylamino, CN, carboxy, C.sub.1 -C.sub.6 -alkoxycarbonyl, phenyl, C.sub.1 -C.sub.6 -alkylphenyl or trifluoromethylphenyl, their pyridine-N-oxides and physiologically acceptable salts thereof, processes for their preparation and medicines containing such compounds as active ingredients.
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