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公开(公告)号：US07579365B2
公开(公告)日：2009-08-25
申请号：US10309204
申请日：2002-12-04
Applicant: Bernd Nickel , Istvan Szelenyi , Jürgen Schmidt , Peter Emig , Dietmar Reichert , Eckhard Günther , Kay Brune , Guillaume Le Baut
Inventor： Bernd Nickel , Istvan Szelenyi , Jürgen Schmidt , Peter Emig , Dietmar Reichert , Eckhard Günther , Kay Brune , Guillaume Le Baut
IPC: A61K31/44 , C07D401/00
CPC classification number: A61K31/496 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/444 , A61K31/4709 , C07D209/14 , C07D401/12 , C07D401/14 , C07D403/12
Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents and to a pharmaceutical composition having antitumor action, characterized in that it contains at least one of the compounds of the general formula 1, if appropriate also in the form of the physiologically tolerable acid addition salts or N-oxides. Furthermore, the invention also includes antitumor agents comprising as active compound one or more N-substituted indole-3-glyoxylamides according to the general formula 1 and, if appropriate, their physiologically tolerable acid addition salts and, if possible, N-oxides and a pharmaceutically utilizable carrier and/or diluent or auxiliary substance in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments.
Abstract translation: 本发明涉及通式I的N-取代的吲哚-3-乙醛酰胺作为抗肿瘤剂和具有抗肿瘤作用的药物组合物的用途，其特征在于其含有至少一种通式1的化合物，如果 也适用于生理上可耐受的酸加成盐或N-氧化物的形式。 此外，本发明还包括抗肿瘤剂，其包含根据通式1的一种或多种N-取代的吲哚-3-乙醛酰胺作为活性化合物，以及如果合适的话，其生理上可耐受的酸加成盐，以及如果可能的话，N-氧化物和 片剂，包衣片剂，胶囊，输注溶液或安瓿，栓剂，贴剂，可通过吸入，悬浮液，霜剂和软膏使用的粉末制剂的药学上可用的载体和/或稀释剂或辅助物质。
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公开(公告)号：US20080153875A1
公开(公告)日：2008-06-26
申请号：US12074845
申请日：2008-03-06
Applicant: Peter Emig , Gerald Bacher , Dietmar Reichert , Silke Basner , Beate Aue , Bernd Nickel , Eckhard Gunther
Inventor： Peter Emig , Gerald Bacher , Dietmar Reichert , Silke Basner , Beate Aue , Bernd Nickel , Eckhard Gunther
IPC: A61K31/4725 , C07D209/04 , A61K31/404 , C07D401/12
CPC classification number: C07D401/12 , C07D209/18
Abstract: The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
Abstract translation: 本发明涉及通式1的新型吲哚衍生物，其制备方法及其用作药物，特别是用于治疗肿瘤。
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公开(公告)号：US07026310B2
公开(公告)日：2006-04-11
申请号：US11105622
申请日：2005-04-14
Applicant: Peter Emig , Eckhard Günther , Jürgen Schmidt , Bernd Nickel , Bernhard Kutscher
Inventor： Peter Emig , Eckhard Günther , Jürgen Schmidt , Bernd Nickel , Bernhard Kutscher
IPC: C07D403/12 , C07D403/14 , A61K31/55 , A61P35/00
CPC classification number: C07D401/06 , C07D215/50
Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
Abstract translation: 本发明涉及式1的新型喹啉衍生物，其制备方法及其用作药物，特别是用于治疗肿瘤。
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公开(公告)号：US20050009809A1
公开(公告)日：2005-01-13
申请号：US10879280
申请日：2004-06-29
Applicant: Matthias Gerlach , Peter Emig , Klaus Paulini , Michael Czech , Tilman Schuster , Eckhard Gunther
Inventor： Matthias Gerlach , Peter Emig , Klaus Paulini , Michael Czech , Tilman Schuster , Eckhard Gunther
IPC: A61K31/496 , A61K31/551 , C07D219/04 , C07D219/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D493/04 , C07
CPC classification number: C07D219/04 , C07D219/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D493/04
Abstract: The invention relates to novel acridine derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for the treatment of tumors.
Abstract translation: 本发明涉及式1的新型吖啶衍生物，其制备及其用作药物，特别是用于治疗肿瘤。
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公开(公告)号：US06706722B2
公开(公告)日：2004-03-16
申请号：US09910142
申请日：2001-07-20
Applicant: Peter Emig , Eckhard Günther , Bernd Nickel , Gerhard Bacher , Silke Baasner , Thomas Beckers , Beate Aue
Inventor： Peter Emig , Eckhard Günther , Bernd Nickel , Gerhard Bacher , Silke Baasner , Thomas Beckers , Beate Aue
IPC: A61K31505
CPC classification number: C07D219/04
Abstract: The invention relates to novel acridine derivatives of formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
Abstract translation: 本发明涉及式1的新型吖啶衍生物，其制备及其用作药物，特别是用于治疗肿瘤。
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Patent Agency Ranking
6.发明授权Indolyl-3-glyoxylic acid derivatives having therapeutically valuable properties 失效具有治疗有价值性质的吲哚基-3-乙醛酸衍生物公开(公告)号：US06693119B2
公开(公告)日：2004-02-17
申请号：US09492531
申请日：2000-01-27
Applicant: Bernd Nickel , Gerald Bacher , Thomas Klenner , Thomas Beckers , Peter Emig , Jürgen Engel , Erik Bruyneel , Günter Kamp , Kirsten Peters
Inventor： Bernd Nickel , Gerald Bacher , Thomas Klenner , Thomas Beckers , Peter Emig , Jürgen Engel , Erik Bruyneel , Günter Kamp , Kirsten Peters
IPC: A61K3144
CPC classification number: A61K31/496 , A61K31/404 , A61K31/4178 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4709
Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general Formula I and to pharmaceutical compositions having antitumor action.
Abstract translation: 本发明涉及通式I的N-取代吲哚-3-乙醛酰胺与具有抗肿瘤作用的药物组合物的用途。
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7.发明授权N-substituted indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action 有权具有抗哮喘，抗过敏和免疫抑制剂/免疫调节作用的N-取代吲哚-3-乙醛酰胺公开(公告)号：US06344467B1
公开(公告)日：2002-02-05
申请号：US09409263
申请日：1999-09-30
Applicant: Guillaume Lebaut , Cécilia Menciu , Bernhard Kutscher , Peter Emig , Stefan Szelenyi , Kay Brune
Inventor： Guillaume Lebaut , Cécilia Menciu , Bernhard Kutscher , Peter Emig , Stefan Szelenyi , Kay Brune
IPC: A61K31496
CPC classification number: C07D401/06 , C07D209/22 , C07D401/12 , C07D401/14
Abstract: The invention relates to novel N-substituted indole-3-glyoxylamides, to processes for their preparation and to their pharmaceutical use. The compounds have antiasthmatic, antiallergic and immunosuppressant/immunomodulating actions.
Abstract translation: 本发明涉及新的N-取代的吲哚-3-乙醛酰胺，其制备方法及其药物用途。 该化合物具有止喘，抗过敏和免疫抑制剂/免疫调节作用。
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8.发明授权
公开(公告)号：US5959115A
公开(公告)日：1999-09-28
申请号：US064790
申请日：1998-04-23
Applicant: Alfred Olbrich , Peter Emig , Bernhard Kutscher , Karl-Friedrich Landgraf , Siegfried Pauluhn , Hans Stange
Inventor： Alfred Olbrich , Peter Emig , Bernhard Kutscher , Karl-Friedrich Landgraf , Siegfried Pauluhn , Hans Stange
IPC: A61P25/04 , C07B61/00 , C07D213/75
CPC classification number: C07D213/75
Abstract: A process for preparation of pure flupertine maleate and the pure A crystalline form of flupertine maleate by the use of water soluble alcohols during synthesis and/or purification.
Abstract translation: 在合成和/或纯化期间通过使用水溶性醇制备马来酸氟普汀和纯马来酸氟普汀的纯A型的方法。
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公开(公告)号：US07989453B2
公开(公告)日：2011-08-02
申请号：US12004168
申请日：2007-12-20
Applicant: Peter Emig , Gerald Bacher , Dietmar Reichert , Silke Basner , Beate Aue , Bernd Nickel , Eckhard Gunther
Inventor： Peter Emig , Gerald Bacher , Dietmar Reichert , Silke Basner , Beate Aue , Bernd Nickel , Eckhard Gunther
IPC: A61K31/67 , A61K31/445 , A61K31/495 , C07D215/38 , C07D215/36 , C07D401/06 , C07D471/08
CPC classification number: C07D401/12 , C07D209/18
Abstract: The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
Abstract translation: 本发明涉及通式1的新型吲哚衍生物，其制备方法及其用作药物，特别是用于治疗肿瘤。
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公开(公告)号：US20080108819A1
公开(公告)日：2008-05-08
申请号：US12004168
申请日：2007-12-20
Applicant: Peter Emig , Gerald Bacher , Dietmar Reichert , Silke Basner , Beate Aue , Bernd Nickel , Eckhard Gunther
Inventor： Peter Emig , Gerald Bacher , Dietmar Reichert , Silke Basner , Beate Aue , Bernd Nickel , Eckhard Gunther
IPC: C07D209/42 , C07D401/06
CPC classification number: C07D401/12 , C07D209/18
Abstract: The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
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