A motor-operated, direct-pressure type mold clamping mechanism capable of high-speed mold closing and opening operations and of producing a required mold clamping force, without the use of a large-sized motor. In the mold opening and closing operations, a ball screw, in engagement with a ball nut which is movable in unison with a moving platen, is rotated at high speed by a coarse-adjustment motor through gears, so that a die is opened and closed at high speed. In the mold clamping operation, the ball screw is driven by a fine-adjustment motor through a clutch and gears which, having a high reduction ratio, serve to enhance the rotatory force and provide greater clamping force.