发明授权
- 专利标题： Hexa-cyclic camptothecin derivatives
- 专利标题（中）： 六环喜树碱衍生物
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申请号： US207718申请日： 1988-06-16
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公开(公告)号： US4939255A公开(公告)日： 1990-07-03
- 发明人: Hiroaki Tagawa , Masamichi Sugimori , Hirofumi Terasawa , Akio Ejima , Satoru Ohsuki
- 申请人： Hiroaki Tagawa , Masamichi Sugimori , Hirofumi Terasawa , Akio Ejima , Satoru Ohsuki
- 申请人地址： JPX Tokyo JPX Tokyo
- 专利权人： Daiichi Pharmaceutical Co., Ltd.,Kabushiki Kaisha Yakult Honsha
- 当前专利权人： Daiichi Pharmaceutical Co., Ltd.,Kabushiki Kaisha Yakult Honsha
- 当前专利权人地址： JPX Tokyo JPX Tokyo
- 优先权： JPX62-156990 19870624; JPX63-005503 19880113
- 主分类号： C07D471/22
- IPC分类号： C07D471/22 ; C07D491/22 ; C07D495/22
摘要：
A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound through Friedlaender reaction. It has an excellent antitumor activity and a high degree of safety, and can be applied as an antitumor medicine for curing tumors of various kinds.
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