发明授权
US4948784A Platinum containing pullulan derivatives and compositions containing the
same
失效
含铂的支链淀粉衍生物和含有其的组合物
- 专利标题: Platinum containing pullulan derivatives and compositions containing the same
- 专利标题(中): 含铂的支链淀粉衍生物和含有其的组合物
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申请号: US163961申请日: 1988-01-20
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公开(公告)号: US4948784A公开(公告)日: 1990-08-14
- 发明人: Fumio Mori , Masafumi Okada , Shuji Miki , Iwao Ebashi , Takashi Nishida , Kouichiro Kawai , Tazuko Tashiro , Shigeru Tsukagoshi
- 申请人: Fumio Mori , Masafumi Okada , Shuji Miki , Iwao Ebashi , Takashi Nishida , Kouichiro Kawai , Tazuko Tashiro , Shigeru Tsukagoshi
- 申请人地址: JPX Kurashiki
- 专利权人: Kuraray Company, Ltd.
- 当前专利权人: Kuraray Company, Ltd.
- 当前专利权人地址: JPX Kurashiki
- 优先权: JPX61-117969 19860521; JPX62-52273 19870306
- 主分类号: C08B37/00
- IPC分类号: C08B37/00
摘要:
A pullulan derivative having one or more active sites resulting from introduction of sulfuric acid, phosphoric acid, a sulfonic acid or a carboxylic acid, wherein one hydrogen atom of the group of the formula ##STR1## occurring at said active sites is partly substituted by a group of the general formula ##STR2## wherein L.sup.1 and L.sup.2 each independently is ammine or a unidentate ligand amine or combinedly represent a bidentate ligand amine and Y is an anionic ligand, and/or two hydrogen atoms of the group ##STR3## or of two ##STR4## groups bound to one and the same carbon atom or to two neighboring carbon atoms as occurring at said active sites are, each independently, partly substituted by a group of the general formula ##STR5## wherein L.sup.1 and L.sup.2 are as defined above, and a pharmacologically acceptable salt thereof.The above compound has anticancer activity and is useful as anticancer agents.The present invention is concerned with said compound, a process for producing the same and a pharmaceutical use thereof.