公开(公告)号：US4948784A

公开(公告)日：1990-08-14

申请号：US163961

申请日：1988-01-20

申请人： Fumio Mori ,  Masafumi Okada ,  Shuji Miki ,  Iwao Ebashi ,  Takashi Nishida ,  Kouichiro Kawai ,  Tazuko Tashiro ,  Shigeru Tsukagoshi

发明人： Fumio Mori ,  Masafumi Okada ,  Shuji Miki ,  Iwao Ebashi ,  Takashi Nishida ,  Kouichiro Kawai ,  Tazuko Tashiro ,  Shigeru Tsukagoshi

IPC分类号： C08B37/00

CPC分类号： C08B37/0018

摘要： A pullulan derivative having one or more active sites resulting from introduction of sulfuric acid, phosphoric acid, a sulfonic acid or a carboxylic acid, wherein one hydrogen atom of the group of the formula ##STR1## occurring at said active sites is partly substituted by a group of the general formula ##STR2## wherein L.sup.1 and L.sup.2 each independently is ammine or a unidentate ligand amine or combinedly represent a bidentate ligand amine and Y is an anionic ligand, and/or two hydrogen atoms of the group ##STR3## or of two ##STR4## groups bound to one and the same carbon atom or to two neighboring carbon atoms as occurring at said active sites are, each independently, partly substituted by a group of the general formula ##STR5## wherein L.sup.1 and L.sup.2 are as defined above, and a pharmacologically acceptable salt thereof.The above compound has anticancer activity and is useful as anticancer agents.The present invention is concerned with said compound, a process for producing the same and a pharmaceutical use thereof.

公开(公告)号：US5100877A

公开(公告)日：1992-03-31

申请号：US282398

申请日：1988-12-05

申请人： Fumio Mori ,  Masafumi Okada ,  Shuji Miki ,  Iwao Ebashi ,  Takashi Nishida ,  Kouichiro Kawai ,  Tazuko Tashiro ,  Shigeru Tsukagoshi

发明人： Fumio Mori ,  Masafumi Okada ,  Shuji Miki ,  Iwao Ebashi ,  Takashi Nishida ,  Kouichiro Kawai ,  Tazuko Tashiro ,  Shigeru Tsukagoshi

IPC分类号： C08B37/00

CPC分类号： C08B37/0018 ,  Y10S514/908

摘要： A pullulan derivative having one or more active sites resulting from introduction of sulfuric acid, phosphoric acid, a sulfonic acid or a carboxylic acid, wherein one hydrogen atom of the group of the formula ##STR1## occurring at said active sites is partly substituted by a group of the general formula ##STR2## wherein L.sup.1 and L.sup.2 each independently is amine or a unidentate ligand amine or combinedly represent a bidentate ligand amine and Y is an anionic ligand, and/or two hydrogen atoms of the group ##STR3## groups bound to one and the same carbon atom or to two neighboring carbon atoms as occurring at said active sites are, each independently, partly substituted by a group of the general formula ##STR4## wherein L.sup.1 and L.sup.2 are as defined above, and a pharmacologically acceptable salt thereof.The above compound has anticancer activity and is useful as anticancer agents.The present invention is concerned with said compound, a process for producing the same and a pharmaceutical use thereof.

摘要翻译： 具有由引入硫酸，磷酸，磺酸或羧酸产生的一个或多个活性位点的支链淀粉衍生物，其中在所述活性位点发生的式“IMAGE”基团的一个氢原子部分被 通式为“IMAGE”的基团，其中L1和L2各自独立地为胺或一元配体胺，或者组合表示二齿配体胺，Y为阴离子配位体，和/或组中的两个氢原子结合至 在所述活性位点处发生的同一个碳原子或两个相邻的碳原子各自独立地部分地被通式“IMAGE”所示的基团取代，其中L1和L2如上所定义，及其药理学上可接受的盐 。 上述化合物具有抗癌活性，可用作抗癌剂。 本发明涉及所述化合物，其制备方法及其药物用途。