发明授权
- 专利标题： Pyrimidine derivatives as an antiviral agent
- 专利标题（中）： 嘧啶衍生物作为抗病毒剂
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申请号： US414784申请日： 1989-09-29
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公开(公告)号： US4956346A公开(公告)日： 1990-09-11
- 发明人: Robert W. Lambert , Joseph A. Martin , Gareth J. Thomas
- 申请人： Robert W. Lambert , Joseph A. Martin , Gareth J. Thomas
- 申请人地址： NJ Nutley
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： NJ Nutley
- 优先权： GBX8619630 19860812
- 主分类号： C07D405/04
- IPC分类号： C07D405/04 ; A61K31/505 ; A61K31/70 ; A61K31/7042 ; A61K31/7052 ; A61K31/7064 ; A61K31/7068 ; A61K31/7072 ; A61P31/12 ; C07H19/06 ; C12N9/99
摘要：
Compounds of the formula ##STR1## wherein A is C.sub.1-8 -alkylene, R.sup.1 is halogen, C.sub.1-4 -alkyl or halo-(C.sub.1-4 -alkyl), R.sup.2 is hydrogen, hydroxy or acyloxy, R.sup.3 is hydrogen or C.sub.1-4 -alkyl, R.sup.4 is aryl or aryloxy and X is O or NH,and tautomers thereof are described. The compounds of formula I and their tautomers possess antiviral activity and can be used in the form of medicaments for the control and prevention of viral infections.