A self-healing tire containing an inner tube is obtained by a method comprising coating either the surface of the tube or the inner surface of a tire casing with a tacky, non-flowing sealant material. Prior to insertion of the inner tube, the surface of the sealant or the opposing surface of the tube or casing or both are coated with a anti-tack material, such as a plasticizer for the sealant. The anti-tack material renders the sealant non-tacky for a period of time long enough for insertion and inflation of the tube. However, the anti-tack material allows the sealant surface to become tacky again thereby adhering the tube to the casing and providing for sealing of the tube when it is punctured.