- 专利标题: Aryloxyphenylpropylamines and their preparation and use
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申请号: US277561申请日: 1988-11-29
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公开(公告)号: US4962122A公开(公告)日: 1990-10-09
- 发明人: Palle Jakobsen , Jorgen Drejer
- 申请人: Palle Jakobsen , Jorgen Drejer
- 申请人地址: DKX Soborg
- 专利权人: A/S Ferrosan
- 当前专利权人: A/S Ferrosan
- 当前专利权人地址: DKX Soborg
- 优先权: DKX6309/87 19871201
- 主分类号: A61K31/135
- IPC分类号: A61K31/135 ; A61K31/275 ; A61K31/33 ; A61K31/357 ; A61K31/36 ; A61P3/00 ; A61P3/14 ; A61P9/00 ; A61P9/08 ; A61P9/10 ; A61P25/04 ; A61P25/06 ; A61P25/08 ; C07C213/02 ; C07C217/48 ; C07C255/54 ; C07D317/64 ; C07D521/00
摘要:
Novel aryloxyphenylpropylamines having the formula ##STR1## wherein R.sup.1 is C.sub.3-7 -cycloalkyl, C.sub.3-10 -alkyl, or alkenyl which may be straight, branched or cyclic, unsubstituted or substituted with C.sub.1-4 -alkoxy, aryloxy or cycloalkyl or cycloalkylalkyl; andR.sup.2 is 3,4-methylenedioxyphenyl, aryl or heteroaryl, which are optionally substituted with one or more cyano, halogen, C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy, C.sub.1-6 -alkenyl, trifluoromethyl, C.sub.3-5 -alkylene, aryloxy or aralkoxyand a salt thereof with a pharmaceutically acceptable acid.The novel compounds are useful in the treatment of anoxia, migraine, ischemia and epilepsy.
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