发明授权
- 专利标题: dsRNA-based prevention of viral escape
- 专利标题(中): 基于dsRNA的病毒逃逸预防
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申请号: US242341申请日: 1988-09-09
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公开(公告)号: US4963532A公开(公告)日: 1990-10-16
- 发明人: William A. Carter
- 申请人: William A. Carter
- 申请人地址: MD Rockville
- 专利权人: HEM Research, Inc.
- 当前专利权人: HEM Research, Inc.
- 当前专利权人地址: MD Rockville
- 主分类号: C07H21/02
- IPC分类号: C07H21/02 ; A61K31/70 ; A61K31/80 ; A61P31/12 ; A61P43/00 ; C07H21/00
摘要:
dsRNA reduces the phenomenon of viral escape and cellular damage attendant thereto. Viral escape is a process by which a virus of intracellular pathogen alters its host range or indirectly alters its susceptibility to antiviral or immunological therapies. Viruses do so by causing specific changes in their genomic/antigenic composition and/or by causing the elaboration of factors which enhance destructiveness of cells and their ability to multiply progeny virus. Animals susceptible to viral infections and pathology secondary to antigenic drift may have damage reduced by exposing them to dsRNA which prevents or substantially minimizes viral escape brought about through these mechanisms of molecular rearrangement and/or elaboration of factors which break down the natural host defenses.
公开/授权文献
- US5447644A Method of controlling viscosity of fabric softeners 公开/授权日:1995-09-05