发明授权
- 专利标题： Compositions and methods of treating calcium renal stones
- 专利标题（中）： 治疗钙肾结石的组成和方法
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申请号： US412801申请日： 1989-09-27
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公开(公告)号： US4966776A公开(公告)日： 1990-10-30
- 发明人: Charles Y. C. Pak
- 申请人： Charles Y. C. Pak
- 申请人地址： TX Austin
- 专利权人： Board of Regents, the University of Texas System
- 当前专利权人： Board of Regents, the University of Texas System
- 当前专利权人地址： TX Austin
- 主分类号： A61K31/19
- IPC分类号： A61K31/19
摘要：
Methods and compositions useful for the treatment and prophylaxis of calcium renal stones in persons with hypocitraturia or undergoing allopurinol therapy are disclosed. The methods involve administering potassium citrate compositions to persons afflicted with or susceptible to calcium renal stone formations. A typical dosage scheme involves administering about 30 to 120 meq potassium citrate per day in divided doses. Such treatments are effective in dissolving existing calcium stones and preventing formation of new calcium stones. Moreover, the results of a comparative clinical assay indicate the potassium citrate is superior to sodium citrate in the treatment of uric acid lithiasis. Potassium citrate therapy averts calcium renal stone formation, a complication which is often associated with sodium citrate or sodium bicarbonate alkalinization therapy.
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