发明授权
- 专利标题: Benzopyrrolidinone compounds as bronchospastic agents
- 专利标题(中): 苯并吡咯烷酮化合物作为支气管痉挛剂
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申请号: US391936申请日: 1989-08-10
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公开(公告)号: US4968705A公开(公告)日: 1990-11-06
- 发明人: Gilbert Regnier , Alain Dhainaut , Jacques Duhault , Michel Lonchampt
- 申请人: Gilbert Regnier , Alain Dhainaut , Jacques Duhault , Michel Lonchampt
- 申请人地址: FRX Neuilly-sur-Seine
- 专利权人: Adir et Cie
- 当前专利权人: Adir et Cie
- 当前专利权人地址: FRX Neuilly-sur-Seine
- 优先权: FRX8811057 19880819
- 主分类号: C07D491/056
- IPC分类号: C07D491/056 ; A61K31/4427 ; A61K31/445 ; A61P11/00 ; A61P29/00 ; A61P37/08 ; C07D401/06
摘要:
New benzopyrrolidinone compounds, which can be used as medicaments and correspond to the formula ##STR1## in which: either: R.sub.1 and R.sub.2 together represent, with the bond of the etherocycle to which they are attached, an optionally substituted benzene nucleus and, simultaneously, R.sub.3 and R.sub.4 are hydrogen, (C.sub.1 -C.sub.4)alkyl or (C.sub.5 -C.sub.6)cycloalkyl;or:R.sub.1 is hydrogen, R.sub.4 is a single bond and R.sub.2 and R.sub.3 together represent, with the bond of the heterocycle to which they are bonded, an optionally substituted benzene nucleus; andA is a straight or branched hydrocarbon chain having from 2 to 6 carbon atoms that is optionally substituted by hydroxy;X is a single bond, oxygen or sulphur; andY is hydrogen, halogen or (C.sub.1 -C.sub.5)alkyl or alkoxy.These new compounds and the physiologically tolerable salts thereof can be used therapeutically, especially in the treatment of bronchospastic disorders and inflammations in the ENT area.
公开/授权文献
- US5639442A Contrast media for ultrasonic imaging 公开/授权日:1997-06-17
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