发明授权
- 专利标题: Alkadiene derivatives, and pharmaceutical compositions containing them
- 专利标题(中): 二烯衍生物和含有它们的药物组合物
-
申请号: US381825申请日: 1989-07-19
-
公开(公告)号: US4971979A公开(公告)日: 1990-11-20
- 发明人: Jean-Luc Malleron , Gerard Ponsinet , Gerard Roussel
- 申请人: Jean-Luc Malleron , Gerard Ponsinet , Gerard Roussel
- 申请人地址: FRX Antony
- 专利权人: Rhone-Poulenc Sante
- 当前专利权人: Rhone-Poulenc Sante
- 当前专利权人地址: FRX Antony
- 优先权: FRX8713357 19870928
- 主分类号: C07C49/587
- IPC分类号: C07C49/587 ; A61K31/10 ; A61K31/12 ; A61K31/13 ; A61K31/22 ; A61K31/235 ; A61K31/38 ; C07C45/00 ; C07C49/84 ; C07C67/00 ; C07C69/157 ; C07C69/73 ; C07C213/00 ; C07C225/22 ; C07C229/30 ; C07C229/34 ; C07C229/36 ; C07C229/44 ; C07C253/00 ; C07C255/07 ; C07C255/37 ; C07C255/40 ; C07C255/41 ; C07C255/42 ; C07C313/00 ; C07C323/22 ; C07C323/51 ; C07C323/52 ; C07C323/56 ; C07C323/60 ; C07D211/16 ; C07D317/18 ; C07D317/60 ; C07D335/06
摘要:
Substituted alkadienes of formula: ##STR1## in which R.sub.1 is hydroxy or acetoxy, R.sub.2 is hydrogen, carboxy, alkoxycarbonyl, phenyl or benzoyl, andR.sub.3 is alkylthio or alkoxy and R.sub.4 is naphthoyl or optionally substituted benzoyl,or R.sub.3 is alkoxycarbonyl, cycloalkyloxycarbonyl or cyano and R.sub.4 is alkyl, naphthyl, optionally substituted phenyl, alkylthio, naphthylmethanethio, optionally substituted benzylthio, optionally substituted phenylthio, naphthylthio, phenethylthio or allylthio,or R.sub.3 and R.sub.4 form, with the carbon atom to which they are attached, a ring-system of formula: ##STR2## in which R.sub.5 is hydrogen or alkoxy and X is methylene or S inhibit 5-lipoxygenase and are useful, for example, as anti-inflammatories.
公开/授权文献
- US4498732A Fiber optic splice organizer 公开/授权日:1985-02-12