发明授权
- 专利标题： Vasoconstrictor peptide
- 专利标题（中）： 血管收缩肽
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申请号： US249429申请日： 1988-09-26
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公开(公告)号： US4981950A公开(公告)日： 1991-01-01
- 发明人: Tomoh Masaki , Katsutoshi Goto , Sadao Kimura , Youji Mitsui , Yoshio Yazaki , Masashi Yanagisawa , Hiroki Kurihara
- 申请人： Tomoh Masaki , Katsutoshi Goto , Sadao Kimura , Youji Mitsui , Yoshio Yazaki , Masashi Yanagisawa , Hiroki Kurihara
- 申请人地址： JPX Osaka JPX Osaka
- 专利权人： Takeda Chemical Ind., Ltd.,Director-General of Agency of Industrial Science and Technology of Ministry of International Trade and Industry
- 当前专利权人： Takeda Chemical Ind., Ltd.,Director-General of Agency of Industrial Science and Technology of Ministry of International Trade and Industry
- 当前专利权人地址： JPX Osaka JPX Osaka
- 优先权： JPX62-255381 19871009
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/575
摘要：
Disclosed is a vasoconstrictor peptide called Endothelin having a molecular weight of 2,500.+-.300. Endothelin contains 21 amino acid residues, wherein four cysteines form two sets of S--S bond.In order to obtain the vasoconstrictor factors of the present invention, it is preferable to culture the endothelial cells collected from the vascular inner walls in a serum-free medium.The vasoconstrictor peptides of the present invention can be utilized as hypotension therapeutic agents or local vasoconstrictors to animals including humans.
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