发明授权
US4983616A Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related
compounds
失效
六氢吡咯(2,3-B)吲哚氨基甲酸酯,脲,酰胺和相关化合物
- 专利标题: Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related compounds
- 专利标题(中): 六氢吡咯(2,3-B)吲哚氨基甲酸酯,脲,酰胺和相关化合物
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申请号: US480706申请日: 1990-02-01
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公开(公告)号: US4983616A公开(公告)日: 1991-01-08
- 发明人: Gerard J. O'Malley , Richard C. Allen , John I. White
- 申请人: Gerard J. O'Malley , Richard C. Allen , John I. White
- 申请人地址: NJ Somerville
- 专利权人: Hoechst-Roussel Pharmaceuticals Inc.
- 当前专利权人: Hoechst-Roussel Pharmaceuticals Inc.
- 当前专利权人地址: NJ Somerville
- 主分类号: A61K31/395
- IPC分类号: A61K31/395 ; A61K31/40 ; A61K31/407 ; A61K31/443 ; A61P25/02 ; A61P25/28 ; C07D207/04 ; C07D209/40 ; C07D487/04
摘要:
There are disclosed various compounds of the formula below, ##STR1## where X is O, S, NH, H-loweralkyl, or N-arylloweralkyl;Y is hydrogen, fluorine, chlorine, bromine, nitro, loweralkyl, loweralkoxy, or triloweralkylsilyl;R.sub.1 is loweralkyl, halogen-substituted loweralkyl, aryl, arylloweralkyl, cycloalkyl, heteroaryl or heteroarylloweralkyl;R.sub.2 is hydrogen, loweralkyl or arylloweralkyl;R.sub.3 is loweralkyl or arylloweralkyl;R.sub.4 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, arylloweralkyl, formyl, loweralkylcarbonyl, arylloweralkylcarbonyl or loweralkoxycarbonyl;R.sub.5 is hydrogen or loweralkyl; andm is 0 or 1, with the proviso that when m is O, R.sub.1 may also be hydrogen,which compounds are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.
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