发明授权
- 专利标题: Tertiary alkyl functionalized piperazine derivatives
- 专利标题(中): 叔烷基官能化哌嗪衍生物
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申请号: US428148申请日: 1989-10-27
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公开(公告)号: US4988814A公开(公告)日: 1991-01-29
- 发明人: Magid A. Abou-Gharbia , John P. Yardley , Ian A. Cliffe
- 申请人: Magid A. Abou-Gharbia , John P. Yardley , Ian A. Cliffe
- 申请人地址: NY New York GB2 Maidenhead
- 专利权人: American Home Products Corp.,John Wyeth & Bro.
- 当前专利权人: American Home Products Corp.,John Wyeth & Bro.
- 当前专利权人地址: NY New York GB2 Maidenhead
- 优先权: GBX8909209 19890422
- 主分类号: C07D239/42
- IPC分类号: C07D239/42 ; C07D295/13 ; C07D295/15
摘要:
Compounds of the formula: ##STR1## in which R.sup.1 is alkyl; R.sup.2 and R.sup.3 are alkyl or taken together they are polymethylene, R.sup.2 and R.sup.3 complete a 5-norbornen-2-yl moiety; X is --CO.sub.2 --, --OCO--, --OCO.sub.2 --, --N(R.sup.7)CO--, --NHNHCO--, --ON(R.sup.7)CO--, --CON(R.sup.7)--, --N(R.sup.7)CO.sub.2 --, --OCON(R.sup.7)-- or --N(R.sup.7)CON(R.sup.8)--, wherein R.sup.7 and R.sup.8 are, independently, hydrogen, alkyl, phenyl, benzyl, substituted phenyl or substituted benzyl in which the substituents are halo, alkyl alkoxy, cyano, nitro or perhalomethyl; R.sup.4 is hydrogen or alkyl; R.sup.5 is hydrogen, alkyl, hydroxyalkyl, phenyl, benzyl, substituted phenyl or substituted benzyl in which the substituents are hydroxy, halo, alkyl alkoxy, trifluoromethyl, nitro, cyano, carbalkoxy, carboxamido, amino, alkylamino or dialkylamino; R.sup.6 is phenyl, benzyl, 2-, 3-, or 4-pyridinyl, 2-pyrimidinyl or 2-pyrazinyl any of which may be substituted by one or more hydroxy, halo, alkyl alkoxy, trifluoromethyl, nitro, cyano, carbalkoxy, carboxamido, amino, alkylamino or dialkylamino; n is one of the integers 0, 1, 2, 3, 4 or 5; or a pharmaceutically acceptable salt thereof, with the proviso that when X is --CON(R.sup.7)-- and R.sup.7 is alkyl, R.sup.6 is other than 2-pyrimidinyl, and when X is --CO.sub.2 -- and R.sup.1, R.sup.2 and R.sup.3 are methyl and n is 1, R.sup.6 is other than 3,5-di(trifluoromethyl)phenyl are antidepressant and/or anxiolytic agents.
公开/授权文献
- US4538298A Fixed bandpass tone controlling 公开/授权日:1985-08-27
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