发明授权
- 专利标题： Pasteurella multocida vaccine
- 专利标题（中）： 巴氏杆菌多杀巴斯德疫苗
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申请号： US190533申请日： 1988-05-05
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公开(公告)号： US4999191A公开(公告)日： 1991-03-12
- 发明人: John R. Glisson , Charles L. Hofacre
- 申请人： John R. Glisson , Charles L. Hofacre
- 申请人地址： GA Athens
- 专利权人： University of Georgia Research Foundation, Inc.
- 当前专利权人： University of Georgia Research Foundation, Inc.
- 当前专利权人地址： GA Athens
- 主分类号： A61K39/102
- IPC分类号： A61K39/102
摘要：
Mutogenesis of the Clemson University (CU) vaccine strain of P. multocida with N-methyl-N-nitro-N-nitrosoguanidine resulted in temperature sensitive (TS) mutants which grew at 37.degree. C. but not 42.degree. C. Two mutants, PM#1 and PM#3, were found to provide turkeys with a level of protection against challenge with a virulent serotype 3 P. multocida strain (P-1059) comparable to the protection provided by the CU strain. Intravenous (IV) inoculation of PM#1, PM#3, and CU was used to determine differences in virulence. PM#1 and PM#3 resulted in lower mortality and lameness than the CU strain. Histopathological evaluation of spleens at 24, 48, and 72 hours post IV inoculation demonstrated that the CU strain induced 2 times more splenic necrosis than either PM#1 or PM#3.
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