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1106 条记录 (耗时 0.045 秒)

    Compositions and methods for making sensory neurons
    1.
    发明授权
    Compositions and methods for making sensory neurons 有权

    公开(公告)号：US12129483B2

    公开(公告)日：2024-10-29

    申请号：US17555581

    申请日：2021-12-20

    申请人： University of Georgia Research Foundation, Inc.

    发明人： Nadja Zeltner ,  Vicente Kenyi Saito-Diaz

    IPC分类号： C12N5/0793 ,  A61K35/30

    CPC分类号： C12N5/0619 ,  A61K35/30 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2533/50

    摘要： The three main peripheral sensory neuron (SN) subtypes, nociceptors, mechanoreceptors, and proprioceptors localize to dorsal root ganglia (DRG) and convey sensations such as pain, temperature, pressure and limb movement/position. Disclosed herein is a chemically defined differentiation protocol that generates all three SN subtypes from the same starting population, as well as methods to enrich for each individual subtypes. The protocol yields high efficiency and purity cultures that are electrically active and respond to specific stimuli. Their molecular character and maturity stage are described and evidence for their use as an axotomy model is exemplified. Cell populations and compositions formed from the resulting cells, as well as methods of their use for disease treatment, drug screening, and modeling of human disorders affecting SNs are also provided.

    Prodrugs of L-BHDU and methods of treating viral infections
    9.
    发明授权
    Prodrugs of L-BHDU and methods of treating viral infections 有权

    公开(公告)号：US11945833B2

    公开(公告)日：2024-04-02

    申请号：US17976407

    申请日：2022-10-28

    申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. ,  Anterogen Co., Ltd

    发明人： Uma Sharan Singh ,  Chung Chu

    IPC分类号： C07F9/6558 ,  A61K31/675 ,  A61K45/06 ,  A61P31/22

    CPC分类号： C07F9/65586 ,  A61K31/675 ,  A61K45/06 ,  A61P31/22

    摘要： In an embodiment, the invention is directed to prodrug compounds of L-BHDU according to the chemical structure I:






    Where R1 is a —(CH2)n—O—R1a group or a —(CH2)j—O—C(O)Ok—R2a group;
    R2 is H, a —(CH2)n—O—R1a group or a —(CH2)j—O—C(O)Ok—R2a group;
    R1a is independently a C6-C30 alkyl group, often a C12-C22 alkyl group, often a C14-C20 alkyl group or a C16-C18 alkyl group, often a C16 or C18 alkyl group;
    R2a is independently a C1-C12 alkyl group, often a C2-C6 alkyl group, a C3-C4 alkyl group, an isopropyl, t-butyl or sec-butyl group, or an isopropyl or t-butyl group;
    Each j is independently 1-6, 1-3, often 1 or 2;
    Each k is 0 or 1;
    Each n is independently 1-6, 1-4, 2-4 or 2 or 3; or
    A pharmaceutically acceptable salt, solute or polymorph thereof. Additional embodiments are directed to pharmaceutical compositions based upon the disclosed chemical compounds and methods of treating or reducing the likelihood of VZV, HSV-1 or HSV-2 infections. Methods of synthesizing compounds according to the present invention represent further embodiments of the invention.