发明授权
US5004835A Substituted dicarboxylic
acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides), process for their
production as well as X-ray contrast media containing them
失效
取代的二羧酸 - 双（3,5-二氨基甲酰基-2,4,6-三碘苯胺），其制备方法以及含有它们的X射线造影剂
- 专利标题： Substituted dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides), process for their production as well as X-ray contrast media containing them
- 专利标题（中）： 取代的二羧酸 - 双（3,5-二氨基甲酰基-2,4,6-三碘苯胺），其制备方法以及含有它们的X射线造影剂
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申请号： US271464申请日： 1988-11-15
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公开(公告)号： US5004835A公开(公告)日： 1991-04-02
- 发明人: Peter Blaszkiewicz , Ulrich Speck
- 申请人： Peter Blaszkiewicz , Ulrich Speck
- 申请人地址： DEX Berlin and Bergkamen
- 专利权人： Schering Aktiengesellschaft
- 当前专利权人： Schering Aktiengesellschaft
- 当前专利权人地址： DEX Berlin and Bergkamen
- 优先权： DEX3739098 19871116
- 主分类号： A61K49/04
- IPC分类号： A61K49/04 ; B08B3/00 ; B60S5/00 ; C07C67/00 ; C07C231/00 ; C07C231/02 ; C07C231/12 ; C07C233/67 ; C07C237/46 ; F02B77/00
摘要：
The invention relates to new substituted dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilines), of general formula I ##STR1## in which R.sup.1 means a hydrogen atom, a C.sub.1 -C.sub.4 alkyl radical or R.sup.2, wherein R.sup.1 and R.sup.2 are the same or different,R.sup.2 means a straight-chain or branched-chain C.sub.2 1.varies.C.sub.8 monohydroxyalkyl radical or polyhydroxyalkyl radical,R.sup.3 means a hydrogen atom, a C.sub.1 -C.sub.4 alkyl radical or R.sup.2,R.sup.4 means a hydrogen atom or a C.sub.1 -C.sub.4 alkyl radical, andn=1 or 2.The new nonionic compounds of formula I because of their good pharmacological and physiocochemical properties are outstandingly suitable as radiopaque substances in X-ray contrast media for use in all the fields of applications of X-ray contrast media.
公开/授权文献
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