发明授权
- 专利标题: Condensed diazepinones, processes for preparing them and pharmaceutical compositions containing these compounds
- 专利标题(中): 浓缩二氮杂酮,其制备方法和含有这些化合物的药物组合物
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申请号: US358740申请日: 1989-05-30
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公开(公告)号: US5006522A公开(公告)日: 1991-04-09
- 发明人: Wolfhard Engel , Wolfgang Eberlein , Gerhard Mihm , Gunther Trummlitz , Norbert Mayer , Adriaan De Jonge
- 申请人: Wolfhard Engel , Wolfgang Eberlein , Gerhard Mihm , Gunther Trummlitz , Norbert Mayer , Adriaan De Jonge
- 申请人地址: DEX Biberach an der Riss
- 专利权人: Karl Thomae GmbH
- 当前专利权人: Karl Thomae GmbH
- 当前专利权人地址: DEX Biberach an der Riss
- 优先权: DEX3818299 19880530
- 主分类号: C07D243/14
- IPC分类号: C07D243/14 ; A61K31/00 ; A61K31/55 ; A61K31/551 ; A61K31/5513 ; A61P1/08 ; A61P9/04 ; A61P25/00 ; A61P25/08 ; A61P25/28 ; C07D243/38 ; C07D405/12 ; C07D471/04 ; C07D471/14 ; C07D487/04 ; C07D487/14 ; C07D495/04
摘要:
Novel condensed diazepinone of general formula I are described, ##STR1## wherein B represents one of the divalent groups ##STR2## and X.sup.1, X.sup.2, A.sup.1, A.sup.2 and R.sup.1 to R.sup.10 are as defined in herein useful as vagal pacemakers for treating bradycardia and bradyarrhythmia. The novel diazepinones also have spasmolytic properties on peripheral organs, antiemetic properties and are capable of promoting cerebral blood flow.
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