发明授权
- 专利标题: Alkylamino- and alkylamino alkyl diarylketones
- 专利标题(中): 烷基氨基和烷基氨基烷基二芳基酮
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申请号: US561202申请日: 1990-07-31
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公开(公告)号: US5006563A公开(公告)日: 1991-04-09
- 发明人: R. Richard L. Hamer , Brian Freed , Richard C. Allen
- 申请人: R. Richard L. Hamer , Brian Freed , Richard C. Allen
- 申请人地址: NJ Somerville
- 专利权人: Hoechst-Roussel Pharmaceuticals Inc.
- 当前专利权人: Hoechst-Roussel Pharmaceuticals Inc.
- 当前专利权人地址: NJ Somerville
- 主分类号: C07C45/00
- IPC分类号: C07C45/00 ; C07C45/45 ; C07C49/233 ; C07C49/80 ; C07C217/86 ; C07C225/16 ; C07C225/22
摘要:
This invention relates to alkylamino and alkyl amino alkyl diarylketones of the formula ##STR1## where Ar is aryl of the formula ##STR2## where V is hydrogen, halogen, loweralkyl, loweralkoxy, CF.sub.3, No.sub.2 and u is an integer of 1 to 3; X and Y are independently CH.sub.2 --, --CH.sub.2 -- or --CHF--; Z and W are independently --CH.sub.2 --, --O--, --CHOH--, or --CHF--; m, n, p, q and t are integers which are independently 0 or 1; R.sub.1 is H or loweralkyl; R.sub.2 and R.sub.3 are loweralkyl; and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as analgesic agents and as agents for alleviating various memory dysfunctions, characterized by a decreased cholinergic function, such as Alzheimer's disease.
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