发明授权
- 专利标题： Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
- 专利标题（中）： 用于生产表鬼臼毒素和相关化合物的中间体及其制备和使用方法
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申请号： US379747申请日： 1989-07-14
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公开(公告)号： US5011948A公开(公告)日： 1991-04-30
- 发明人: Dolatrai M. Vyas , Paul M. Skonezny
- 申请人： Dolatrai M. Vyas , Paul M. Skonezny
- 申请人地址： NY New York
- 专利权人： Bristol-Myers Company
- 当前专利权人： Bristol-Myers Company
- 当前专利权人地址： NY New York
- 主分类号： C07C51/347
- IPC分类号： C07C51/347 ; C07C51/353 ; C07C51/367 ; C07C51/377 ; C07C62/32 ; C07C62/34 ; C07D261/20 ; C07D307/92 ; C07D317/70 ; C07D493/04 ; C07D498/04
摘要：
There is provided a novel and efficient stereoselective total synthesis of epipodophyllotoxin and related epipodophyllotoxin compounds of the general formula ##STR1## wherein R.sup.1 and R.sup.2 each are independently hydrogen or (lower)alkoxy, or R.sup.1 and R.sup.2, taken together, is methylenedioxy; R.sup.4 and R.sup.6 each are independently hydrogen or (lower)alkoxy; and R.sup.5 is hydrogen or a phenol-protecting group; or an acid addition salt thereof. The present invention also provides novel intermediates and processes for the preparation of said intermediates, which are then converted into known antineoplastic agents.
公开/授权文献
- US5580254A Communication aid 公开/授权日：1996-12-03
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