An anti-skid brake control system is associated with a control system for a power train which controls power train operation mode between a four-wheel drive mode, in which all four wheels are coupled with an automotive internal combustion engine to be distributed torque according to a controlled distribution ratio of an engine driving torque, and a two-wheel drive mode, in which two auxiliary driving wheels are disconnected from the engine to be free from engine driving torque and two driving wheels are connected to the engine to receive the engine driving torque. The anti-skid brake control system is so associated with the power train control system as to normally set the power train operation mode into the two-wheel drive mode during active state of anti-skid brake control, and to set the power train operation mode into the four-wheel driven mode in response to wheel slippage at the primary driving wheels greater than a predetermined threshold value.