发明授权
- 专利标题： 2-substituted ergolines
- 专利标题（中）： 2-取代的麦角碱
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申请号： US380352申请日： 1989-07-17
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公开(公告)号： US5037832A公开(公告)日： 1991-08-06
- 发明人: Thomas Brumby , Gerhard Sauer , Josef Heindl , Jonathan Turner , Gerhard Kuhne , Helmut Wachtel
- 申请人： Thomas Brumby , Gerhard Sauer , Josef Heindl , Jonathan Turner , Gerhard Kuhne , Helmut Wachtel
- 申请人地址： DEX Berlin and Bergkamen
- 专利权人： Schering Aktiengesellschaft
- 当前专利权人： Schering Aktiengesellschaft
- 当前专利权人地址： DEX Berlin and Bergkamen
- 优先权： DEX3824661 19880715; DEX3917268 19890523
- 主分类号： A61K31/48
- IPC分类号： A61K31/48 ; A61P25/00 ; A61P43/00 ; C07D457/12
摘要：
2-Substituted ergolines ##STR1## wherein C.sub.2 C.sub.3 and C.sub.9 C.sub.10 represent a single or double bond;X is oxygen or sulfur;R.sup.2 is C.sub.1-10 alkyl, optionally halogen-substituted C.sub.2-10 alkenyl, CH.sub.2 YR.sup.3, CR.sup.12 (OR.sup.4)R.sup.5, CH.sub.2 -CHR.sup.9 -COR.sup.10 or COR.sup.12, whereinY is oxygen or sulfur,R.sup.3 is hydrogen, C.sub.1-4 alkyl, phenyl, C.sub.2-5 acyl or phenyl C.sub.1-4 alkyl,R.sup.4 is hydrogen or C.sub.2-5 acyl,R.sup.5 is C.sub.1-9 alkyl,R.sup.9 is COCH.sub.3 or COO-C.sub.1-4 alkyl,R.sup.10 is C.sub.1-4 alkyl or O-C.sub.1-4 alkyl,R.sup.12 is hydrogen or C.sub.1-9 alkyl; andR.sup.6 is C.sub.2-10 alkyl, C.sub.3-10 alkenyl or C.sub.4-10 cycloalkyl-C.sub.1-3 -alkyl,and acid addition salts, isomers and isomeric mixtures thereof are dopaminergic agonists and useful for treating Parkinson's Disease.
公开/授权文献
- US5531645A Amusement ride 公开/授权日：1996-07-02
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