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4 条记录 (耗时 0.024 秒)

    2-substituted ergolines
    1.
    发明授权
    2-substituted ergolines 失效
    2-取代的麦角碱

    公开(公告)号：US5158957A

    公开(公告)日：1992-10-27

    申请号：US720996

    申请日：1991-06-26

    申请人： Thomas Brumby ,  Gerhard Sauer ,  Josef Heindl ,  Jonathan Turner ,  Gerhard Kuhne ,  Helmut Wachtel

    发明人： Thomas Brumby ,  Gerhard Sauer ,  Josef Heindl ,  Jonathan Turner ,  Gerhard Kuhne ,  Helmut Wachtel

    IPC分类号： A61K31/48 ,  A61P25/00 ,  A61P43/00 ,  C07D457/12

    CPC分类号： C07D457/12

    摘要： 2-Substituted ergolines ##STR1## wherein C.sub.2 C.sub.3 and C.sub.9 C.sub.10 represent a single of double bond;X is oxygen or sulfur;R.sup.2 is C.sub.1-10 alkyl, optionally halogen-substituted C.sub.2-10 alkenyl, CH.sub.2 YR.sup.3, CR.sup.12 (OR.sup.4)R.sup.5, CH.sub.2 --CHR.sup.9 --COR.sup.10 or COR.sup.12, whereinY is oxygen or sulfur,R.sup.3 is hydrogen, C.sub.1-4 alkyl, phenyl, C.sub.2-5 acyl or phenyl C.sub.1-4 alkyl,R.sup.4 is hydrogen or C.sub.2-5 acyl,R.sup.5 is C.sub.1-9 alkyl,R.sup.9 is COCH.sub.3 or COO-C.sub.1-4 alkyl,R.sup.10 is C.sub.1-4 alkyl or O-C.sub.1-4 alkyl,R.sup.12 is hydrogen or C.sub.1-9 alkyl; andR.sup.6 is C.sub.2-10 alkyl, C.sub.3-10 alkenyl or C.sub.4-10 cycloalkyl-C.sub.1-3 -alkyl,and acid addition salts, isomers and isomeric mixtures thereof are dopaminergic agonists and useful for treating Parkinson's Disease.

    摘要翻译： 2-取代的ergolines 其中C2 C3和C9 C10表示单键的双键; X是氧或硫; R 2是C 1-10烷基，任选被卤素取代的C 2-10烯基，CH 2 YR 3，CR 12（OR 4）R 5，CH 2 -CHR 9 -CON 10或COR 12，其中Y是氧或硫，R 3是氢，C 1-4烷基，苯基， C2-5酰基或苯基C1-4烷基，R4是氢或C2-5酰基，R5是C1-9烷基，R9是COCH3或COO-C1-4烷基，R10是C1-4烷基或O-C1-4 烷基，R 12是氢或C 1-19烷基; 并且R 6是C 2-10烷基，C 3-10烯基或C 4-10环烷基-C 1-3烷基，其酸加成盐，异构体和异构体混合物是多巴胺能激动剂，可用于治疗帕金森病。

    2-substituted ergolines
    2.
    发明授权
    2-substituted ergolines 失效
    2-取代的麦角碱

    公开(公告)号：US5037832A

    公开(公告)日：1991-08-06

    申请号：US380352

    申请日：1989-07-17

    申请人： Thomas Brumby ,  Gerhard Sauer ,  Josef Heindl ,  Jonathan Turner ,  Gerhard Kuhne ,  Helmut Wachtel

    发明人： Thomas Brumby ,  Gerhard Sauer ,  Josef Heindl ,  Jonathan Turner ,  Gerhard Kuhne ,  Helmut Wachtel

    IPC分类号： A61K31/48 ,  A61P25/00 ,  A61P43/00 ,  C07D457/12

    CPC分类号： C07D457/12

    摘要： 2-Substituted ergolines ##STR1## wherein C.sub.2 C.sub.3 and C.sub.9 C.sub.10 represent a single or double bond;X is oxygen or sulfur;R.sup.2 is C.sub.1-10 alkyl, optionally halogen-substituted C.sub.2-10 alkenyl, CH.sub.2 YR.sup.3, CR.sup.12 (OR.sup.4)R.sup.5, CH.sub.2 -CHR.sup.9 -COR.sup.10 or COR.sup.12, whereinY is oxygen or sulfur,R.sup.3 is hydrogen, C.sub.1-4 alkyl, phenyl, C.sub.2-5 acyl or phenyl C.sub.1-4 alkyl,R.sup.4 is hydrogen or C.sub.2-5 acyl,R.sup.5 is C.sub.1-9 alkyl,R.sup.9 is COCH.sub.3 or COO-C.sub.1-4 alkyl,R.sup.10 is C.sub.1-4 alkyl or O-C.sub.1-4 alkyl,R.sup.12 is hydrogen or C.sub.1-9 alkyl; andR.sup.6 is C.sub.2-10 alkyl, C.sub.3-10 alkenyl or C.sub.4-10 cycloalkyl-C.sub.1-3 -alkyl,and acid addition salts, isomers and isomeric mixtures thereof are dopaminergic agonists and useful for treating Parkinson's Disease.

    摘要翻译： 2-取代的麦角糖苷其中C2 C3和C9 C10表示单键或双键; X是氧或硫; R 2是C 1-10烷基，任选被卤素取代的C 2-10烯基，CH 2 YR 3，CR 12（OR 4）R 5，CH 2 -CHR 9 -CON 10或COR 12，其中Y是氧或硫，R 3是氢，C 1-4烷基，苯基， C2-5酰基或苯基C1-4烷基，R4是氢或C2-5酰基，R5是C1-9烷基，R9是COCH3或COO-C1-4烷基，R10是C1-4烷基或O-C1-4 烷基，R 12是氢或C 1-19烷基; 并且R 6是C 2-10烷基，C 3-10烯基或C 4-10环烷基-C 1-3烷基，其酸加成盐，异构体和异构体混合物是多巴胺能激动剂，可用于治疗帕金森病。

    Process for the dimerization of hexafluoropropene oxide
    3.
    发明授权
    Process for the dimerization of hexafluoropropene oxide 失效
    六氟环氧丙烷二聚反应的方法

    公开(公告)号：US4303593A

    公开(公告)日：1981-12-01

    申请号：US158929

    申请日：1980-06-12

    申请人： Gerhard Kuhne

    发明人： Gerhard Kuhne

    IPC分类号： C07C59/135 ,  B01J31/00 ,  B01J31/16 ,  C07B61/00 ,  C07C51/00 ,  C07C51/58 ,  C07C67/00

    CPC分类号： C07C51/58

    摘要： In the dimerization of hexafluoropropene oxide to give oligomeric acid fluorides of the formula ##STR1## the ratio of the oligomeric constituents formed is directed, in an improved manner, towards the formation of the dimer (n=0) if the reaction is carried out in the presence of a catalyst system which consists of a mixture of a copper (I) compound and a copper (II) compound mixed with a complex-forming agent from the group of the nitriles, isocyanides, tertiary phosphines and cyclic hydrocarbons with 6 to 12 ring atoms and 2 to 3 double bonds in the ring, and an aprotic organic solvent. The dimer is an intermediate product in the synthesis of perfluoropropyl perfluorovinyl ether, the latter being employed as a comonomer in fluorine-containing copolymers.

    摘要翻译： 在六氟丙烯氧化物的二聚反应中得到下式的低聚酸氟化物，其形成的低聚成分的比例以改进的方式针对二聚体的形成（n = 0），如果反应在 存在催化剂体系，其由铜（I）化合物和铜（II）化合物的混合物组成，其与来自腈，异氰化物，叔膦和环状烃的组合物形成剂混合，具有6至12个 环原子和环中有2至3个双键，以及非质子有机溶剂。 二聚体是全氟丙基全氟乙烯基醚的合成中的中间产物，后者用作含氟共聚物中的共聚单体。