发明授权
- 专利标题： Expression vector for human TNF
- 专利标题（中）： 人TNF的表达载体
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申请号： US402675申请日： 1989-09-05
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公开(公告)号： US5059530A公开(公告)日： 1991-10-22
- 发明人: Takehiro Oshima , Shoji Tanaka , Shigekazu Matsukura
- 申请人： Takehiro Oshima , Shoji Tanaka , Shigekazu Matsukura
- 申请人地址： JPX Osaka
- 专利权人： Suntory Ltd.
- 当前专利权人： Suntory Ltd.
- 当前专利权人地址： JPX Osaka
- 优先权： JPX60-217740 19850930
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/525 ; C12N1/21 ; C12N15/70
摘要：
The present invention provides a vector plasmid capable of efficient tumor necrosis factor (TNF) production, a process capable of efficient TNF production in a host transformed with said plasmid and a composition containing the TNF produced by said process.The novel plasmid of the present invention is characterized by having inserted therein a DNA fragment that has a phage-derived promoter region upstream of a structural gene for TNF and in which a DNA fragment containing an E. coli gene-derived transcription termination coding base sequence (terminator) is joined immediately downstream of a base sequence coding for the termination of translation of said structural gene.
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