发明授权
US5070190A Substituted N-glycosylamides, process for their preparation, and their
use as medicaments
失效
取代的N-甲酰胺,其制备方法及其作为药物的用途
- 专利标题: Substituted N-glycosylamides, process for their preparation, and their use as medicaments
- 专利标题(中): 取代的N-甲酰胺,其制备方法及其作为药物的用途
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申请号: US336497申请日: 1989-04-12
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公开(公告)号: US5070190A公开(公告)日: 1991-12-03
- 发明人: Oswald Lockhoff , John Goossens , Helmut Brunner , Michael Sperzel , Klaus G. Stunkel
- 申请人: Oswald Lockhoff , John Goossens , Helmut Brunner , Michael Sperzel , Klaus G. Stunkel
- 申请人地址: DEX Leverkusen
- 专利权人: Bayer Aktiengesellschaft
- 当前专利权人: Bayer Aktiengesellschaft
- 当前专利权人地址: DEX Leverkusen
- 优先权: DEX3812681 19880416
- 主分类号: A61K31/70
- IPC分类号: A61K31/70 ; A61K31/7028 ; A61P37/04 ; C07H15/12
摘要:
The invention relates to new N-glycosylamides of the general formula I ##STR1## in which R.sup.1 denotes a saturated alkyl radical or a singly, doubly or triply unsaturated alkenyl radical having up to 50 carbon atoms,R.sup.2 denotes a saturated alkyl radical or a singly, doubly or triply unsaturated alkenyl radical having up to 50 carbon atoms,A represents --CO-- or represents a group ##STR2## in which R.sup.3 represents hydrogen, C.sub.1 -C.sub.7 alkyl, hydroxymethyl, 1-hydroxyethyl, mercaptomethyl, 2-methylthioethyl, 3-aminopropyl, 2-ureidopropyl, 3-guanidylpropyl, 4-aminobutyl, carboxymethyl, carbamoylmethyl, 2-carboxyethyl, 2-carbamoylethyl, benzyl, 4-hydroxybenzyl, 3-indolylmethyl or 4-imidazolylmethyl, andn represents 0 to 10,and which are substituted in the sugar residue with an amino acid residue, as well as process for their preparation and their use as medicaments.
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