发明授权
US5084453A 1-carboxy-1-vinyloxyimino aminothiazole cephalosporin derivatives
失效
1-羧基-1-乙烯氧基亚氨基氨基噻唑头孢菌素衍生物
- 专利标题: 1-carboxy-1-vinyloxyimino aminothiazole cephalosporin derivatives
- 专利标题(中): 1-羧基-1-乙烯氧基亚氨基氨基噻唑头孢菌素衍生物
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申请号: US265458申请日: 1988-10-13
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公开(公告)号: US5084453A公开(公告)日: 1992-01-28
- 发明人: Susumu Nakagawa , Ryuji Mitomo , Koji Yamada , Norikazu Otake , Fumio Nakano , Akira Asai , Satoru Kuroyanagi , Yoshiharu Tanaka , Moriaki Ishikawa , Ryosuke Ushijima
- 申请人: Susumu Nakagawa , Ryuji Mitomo , Koji Yamada , Norikazu Otake , Fumio Nakano , Akira Asai , Satoru Kuroyanagi , Yoshiharu Tanaka , Moriaki Ishikawa , Ryosuke Ushijima
- 申请人地址: JPX Tokyo
- 专利权人: Banyu Pharmaceutical Co., Ltd.
- 当前专利权人: Banyu Pharmaceutical Co., Ltd.
- 当前专利权人地址: JPX Tokyo
- 主分类号: A61K31/545
- IPC分类号: A61K31/545 ; C07D235/28 ; C07D263/46 ; C07D263/58 ; C07D271/10 ; C07D271/113 ; C07D277/20 ; C07D277/36 ; C07D277/40 ; C07D277/56 ; C07D285/12 ; C07D285/125 ; C07D501/22 ; C07D501/24 ; C07D501/34 ; C07D501/36 ; C07D501/46
摘要:
The present invention relates to a compound having the formula: ##STR1## wherein R is a hydrogen atom, a carboxyl-protecting group or a negative charge and Q is a hydrogen atom, a halogen atom, a hydroxyl group, an acetoxy group, a carbamoyl group, an azide group, a substituted or unsubstituted quarternary ammonio group or a substituted or unsubstituted heterocyclic thio group having at least one hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, or a non-toxic salt or physiologically hydrolyzable non-toxic ester thereof; a process for producing it; and an antibacterial agent comprising it as an active ingredient.Further, the present invention also relates to a compound having the formula: ##STR2## wherein R.sup.3 is a hydrogen atom or an amino-protecting group, and each of R.sup.4 and R.sup.5 which may be the same or different is a hydrogen atom or a carboxyl-protecting group, or a salt thereof; and a process for producing it.
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