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    Azole derivatives
    1.
    发明授权
    Azole derivatives 失效
    唑衍生物

    公开(公告)号：US07589096B2

    公开(公告)日：2009-09-15

    申请号：US12071808

    申请日：2008-02-26

    申请人： Norikazu Otake ,  Yuji Haga ,  Makoto Jitsuoka ,  Akio Kanatani

    发明人： Norikazu Otake ,  Yuji Haga ,  Makoto Jitsuoka ,  Akio Kanatani

    IPC分类号： A61K31/438 ,  A61K31/506 ,  A61K31/4545 ,  C07D233/96 ,  C07D401/14 ,  C07D401/02

    CPC分类号： C07D491/10

    摘要： The present invention relates to a compound of the formula (I): wherein Az is a group comprising a monocyclic azole or a bicyclic aromatic ring of the same or different fused azoles; T, U, V and W are independently methine or nitrogen, wherein a methine may be optionally substituted by a substituent, and at least two of T, U, V and W are methine groups; and X is nitrogen or methine. The compounds of the present invention are useful as agents for the treatment of various kinds of diseases related to NPY, for example, cardiovascular disorders, nervous system disorders, genitative diseases, metabolic diseases, genital or reproductive disorders, gastro-intestinal disorders, respiratory disorders, inflammatory diseases or glaucoma, and the like.

    摘要翻译： 本发明涉及式（I）化合物：其中Az是包含相同或不同稠合唑的单环唑或双环芳环的基团; T，U，V和W独立地是次甲基或氮，其中次甲基可以任选地被取代基取代，并且T，U，V和W中的至少两个是次甲基; X是氮或次甲基。 本发明的化合物可用作治疗与NPY相关的各种疾病的药剂，例如心血管疾病，神经系统疾病，基因疾病，代谢疾病，生殖器或生殖障碍，胃肠道疾病，呼吸障碍 ，炎症性疾病或青光眼等。

    Novel azole derivatives
    3.
    发明申请
    Novel azole derivatives 失效
    新型唑衍生物

    公开(公告)号：US20080188507A1

    公开(公告)日：2008-08-07

    申请号：US12071808

    申请日：2008-02-26

    申请人： Norikazu Otake ,  Yuji Haga ,  Makoto Jitsuoka ,  Akio Kanatani

    发明人： Norikazu Otake ,  Yuji Haga ,  Makoto Jitsuoka ,  Akio Kanatani

    IPC分类号： A61K31/4747 ,  C07D491/14

    CPC分类号： C07D491/10

    摘要： The present invention relates to a compound of the formula (I): wherein Az is a group comprising a monocyclic azole or a bicyclic aromatic ring of the same or different fused azoles; T, U, V and W are independently methine or nitrogen, said methine being optionally substituted by a substituent, and at least two of T, U, V and W are said methine groups; and X is nitrogen or methine.The compounds of the present invention are useful as agents for the treatment of various kinds of diseases related to NPY, for example, cardiovascular disorders, nervous system disorders, genitative diseases, metabolic diseases, genital or reproductive disorders, gastro-intestinal disorders, respiratory disorders, inflammatory diseases or glaucoma, and the like.

    摘要翻译： 本发明涉及式（I）化合物：其中Az是包含相同或不同稠合唑的单环唑或双环芳环的基团; T，U，V和W独立为次甲基或氮，所述次甲基任选被取代基取代，T，U，V和W中的至少两个为所述次甲基; X是氮或次甲基。 本发明的化合物可用作治疗与NPY相关的各种疾病的药剂，例如心血管疾病，神经系统疾病，基因疾病，代谢疾病，生殖器或生殖障碍，胃肠道疾病，呼吸障碍 ，炎症性疾病或青光眼等。

    Novel Sulfone Amide Amide Derivatives
    4.
    发明申请
    Novel Sulfone Amide Amide Derivatives 失效
    新型磺酰胺酰胺衍生物

    公开(公告)号：US20080161326A1

    公开(公告)日：2008-07-03

    申请号：US10589693

    申请日：2005-02-15

    申请人： Norikazu Otake ,  Yoshio Ogino ,  Akio Kanatani

    发明人： Norikazu Otake ,  Yoshio Ogino ,  Akio Kanatani

    IPC分类号： A61K31/52 ,  C07D235/04 ,  A61K31/4184 ,  A61P3/04 ,  A61P3/10 ,  C07D473/00

    CPC分类号： C07D471/04 ,  C07D235/14 ,  C07D473/00 ,  C07D487/04

    摘要： The present invention relates to compounds of the general formula (I): wherein A, B, C and D each independently are a methine group or a nitrogen atom, said methine group optionally having a substituent(s) with at least one of them meaning the methine group; E means a group represented by the following formulae (E1): R1 means a lower alkyl group or an aryl group optionally having a substituent(s) or means a lower alkylene group linked to arbitrary, linkable position(s) of E, and others. The compounds of the present invention are useful as an agent for the treatment of a variety of diseases related to NPY.

    摘要翻译： 本发明涉及通式（I）的化合物：其中A，B，C和D各自独立地为次甲基或氮原子，所述次甲基任选具有取代基，其中至少一个为含义 次甲基; E表示由下式（E1）表示的基团：R 1表示低级烷基或任选具有取代基的芳基，或指与任意可连接位置连接的低级亚烷基 （E）等。 本发明的化合物可用作治疗与NPY有关的各种疾病的药剂。

    Azole derivatives
    5.
    发明授权
    Azole derivatives 失效
    唑衍生物

    公开(公告)号：US07365079B2

    公开(公告)日：2008-04-29

    申请号：US10536360

    申请日：2003-11-25

    申请人： Norikazu Otake ,  Yuji Haga ,  Makoto Jitsuoka ,  Akio Kanatani

    发明人： Norikazu Otake ,  Yuji Haga ,  Makoto Jitsuoka ,  Akio Kanatani

    IPC分类号： A61K31/4355 ,  C07D471/04

    CPC分类号： C07D491/10

    摘要： The present invention relates to a compound of the formula (I): wherein Az is a group comprising a monocyclic azole or a bicyclic aromatic ring of the same or different fused azoles; T, U, V and W are independently methine or nitrogen, said methine being optionally substituted by a substituent, and at least two of T, U, V and W are said methine groups; and X is nitrogen or methine. The compounds of the present invention are useful as agents for the treatment of various kinds of diseases related to NPY, for example, cardiovascular disorders, nervous system disorders, genitative diseases, metabolic diseases, genital or reproductive disorders, gastrointestinal disorders, respiratory disorders, inflammatory diseases or glaucoma, and the like.

    摘要翻译： 本发明涉及式（I）化合物：其中Az是包含相同或不同稠合唑的单环唑或双环芳环的基团; T，U，V和W独立为次甲基或氮，所述次甲基任选被取代基取代，T，U，V和W中的至少两个为所述次甲基; X是氮或次甲基。 本发明的化合物可用作治疗与NPY相关的各种疾病的药剂，例如心血管疾病，神经系统疾病，基因疾病，代谢疾病，生殖器或生殖障碍，胃肠道疾病，呼吸系统疾病，炎症性疾病 疾病或青光眼等。

    Benzimidazolone derivatives
    6.
    发明授权
    Benzimidazolone derivatives 失效
    苯并咪唑酮衍生物

    公开(公告)号：US07164024B2

    公开(公告)日：2007-01-16

    申请号：US10475447

    申请日：2002-04-19

    申请人： Takeru Yamakawa ,  Yoshio Ogino ,  Yufu Sagara ,  Kenji Matsuda ,  Akira Naya ,  Toshifumi Kimura ,  Norikazu Otake

    发明人： Takeru Yamakawa ,  Yoshio Ogino ,  Yufu Sagara ,  Kenji Matsuda ,  Akira Naya ,  Toshifumi Kimura ,  Norikazu Otake

    IPC分类号： A61K31/44

    CPC分类号： C07D401/14 ,  C07D409/14

    摘要： This invention relates to benzimidazolone derivatives, represented by compounds of a general formula [I] [in which R1 and R2 stand for, e.g., hydrogen atoms; R3a, R3b, R4, R5 stand for, e.g., hydrogen atoms and alkyl groups; R6 stands for e.g., aryl or heteroaryl groups; A ring stands for 5- to 8-membered aliphatic heterocyclic ring containing one nitrogen atom; and Z stands for carbonyl group or sulfonyl group]. The benzimidazolone derivatives of the invention exhibit antagonism to muscarinic acetylcholine receptors, and are useful as treating agent and/or prophylactic of Parkinson's disease, drug-induced parkinsonism, dystonia, akinesia, pancreatitis, bilestone/cholecystitis, biliary dyskinesia, achalasia, pain, itch, cholinergic urticaria, irritable bowel syndrome, vomiting, nausea, dizziness, Meniere's disease, motion sickness and urinary disturbance.

    摘要翻译： 本发明涉及由通式[I] [其中R 1，R 2和R 2]的化合物代表的例如氢原子的苯并咪唑酮衍生物; R 3a，R 3b，R 4，R 5表示例如氢原子和烷基; R 6表示例如芳基或杂芳基; 环代表含有一个氮原子的5-至8-元脂族杂环; Z代表羰基或磺酰基]。 本发明的苯并咪唑酮衍生物对毒蕈碱性乙酰胆碱受体表现出拮抗作用，可用作帕金森病，药物诱发的帕金森综合征，肌张力障碍，运动不良，胰腺炎，胆石，胆囊炎，胆汁运动障碍，贲门失弛缓症，疼痛，瘙痒的治疗剂和/或预防 ，胆碱能性荨麻疹，肠易激综合征，呕吐，恶心，眩晕，梅尼埃病，运动病和尿紊乱。

    Novel benzimidazole derivatives
    7.
    发明申请
    Novel benzimidazole derivatives 失效

    公开(公告)号：US20060205750A1

    公开(公告)日：2006-09-14

    申请号：US11431274

    申请日：2006-05-10

    申请人： Norikazu Otake ,  Minoru Moriya ,  Yoshio Ogino ,  Kenji Matsuda ,  Yoshikazu Nagae ,  Akio Kanatani ,  Takehiro Fukami

    发明人： Norikazu Otake ,  Minoru Moriya ,  Yoshio Ogino ,  Kenji Matsuda ,  Yoshikazu Nagae ,  Akio Kanatani ,  Takehiro Fukami

    IPC分类号： A61K31/4747 ,  A61K31/4184 ,  C07D487/10

    CPC分类号： C07D473/30 ,  C07D405/04 ,  C07D471/04 ,  C07D471/10 ,  C07D473/00 ,  C07D491/04

    摘要： The present invention relates to a compound of the formula (I): (wherein A, B, C and D are independently nitrogen or optionally substituted methine; E is nitrogen, methine or hydroxy substituted methine; n is 0 or 1; T, U, V and W are independently nitrogen or optionally substituted methine; X is —N(SO2R4)—, —N(COR5)— or —CO—; Y is —C(R6)(R7)—, —O— or —N(R8)—, provided that the compound (I) when E is nitrogen, n is 0, X is —CO—, and Y is —O— is excluded) and the like, which are useful as an agent for the treatment of various diseases related to NPY, for example cardiovascular disorders such as angina, acute or congestive heart failure, myocardial infarction, hypertension, nephropathy, electrolyte abnormality, vasospasm, arteriosclerosis, etc., central nervous system disorders such as bulimia, depression, anxiety, seizure, epilepsy, dementia, pain, alcoholism, drug withdrawal, circadian rhythm disorders, schizophrenia, memory impairment, sleep disorders, cognitive impairment, etc., metabolic diseases such as obesity, diabetes, hormone abnormality, hypercholesterolemia, hyperlipidemia, gout, fatty liver, etc., genital or reproductive disorders such as infertility, preterm labor, sexual dysfunction, etc., gastro-intestinal disorders, respiratory disorder, inflammatory diseases or glaucoma, and the like, also for example, atherosclerosis, hypogonadism, hyperandrogenism, polycystic ovary syndrome (Pickwickian syndrome), hirsutism, gastro-intestinal motility disorder, obesity-related gastro-esophageal reflux, obesity hypoventilation, sleep apnea, inflammation, systemic inflammation of the vasculature, osteoarthritis, insulin resistance, bronchoconstriction, alcohol preference, metabolic syndrome, Alzheimer's disease, cardiac hypertrophy, left ventricular hypertrophy, hypertriglyceridemia, low HDL cholesterol, cardiovascular disorders such as coronary heart disease (CHD), cerebrovascular disease, stroke, peripheral vascular disease, sudden death, gallbladder diseases, cancer (breast, endometrial, colon), breathlessness, hyperuricemia, impaired fertility, low back pain, or increased anesthetic risk, and the like.