发明授权
- 专利标题： Preparation of a polymer/interleukin-2 conjugate
- 专利标题（中）： 聚合物/白介素-2缀合物的制备
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申请号： US415046申请日： 1989-09-29
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公开(公告)号： US5089261A公开(公告)日： 1992-02-18
- 发明人: Danute E. Nitecki , Nandini Katre , Robert J. Goodson , Lois Aldwin
- 申请人： Danute E. Nitecki , Nandini Katre , Robert J. Goodson , Lois Aldwin
- 申请人地址： CA Emeryville
- 专利权人： Cetus Corporation
- 当前专利权人： Cetus Corporation
- 当前专利权人地址： CA Emeryville
- 主分类号： A61K47/48
- IPC分类号： A61K47/48
摘要：
The present invention is a process for preparing a pharmaceutical composition comprising a biologically active conjugated protein. It comprises a polyethylene glycol or a polyoxyethylated polyol conjugated to IL-2. This protein is conjugated to reduce its immunogenicity, and increase its solubility, and increase its circulating in vivo half-life.
公开/授权文献
- US6094329A DI protective switching device 公开/授权日：2000-07-25
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