发明授权
US5099035A Mevinic acid derivatives useful as antihypercholesterolemic agents and
method for preparing same
失效
可用作抗高胆固醇血症药的米维酸衍生物及其制备方法
- 专利标题： Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
- 专利标题（中）： 可用作抗高胆固醇血症药的米维酸衍生物及其制备方法
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申请号： US662597申请日： 1991-03-01
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公开(公告)号： US5099035A公开(公告)日： 1992-03-24
- 发明人: Jeffrey O. Saunders , Eric M. Gordon
- 申请人： Jeffrey O. Saunders , Eric M. Gordon
- 申请人地址： NJ Princeton
- 专利权人： E. R. Squibb & Sons, Inc.
- 当前专利权人： E. R. Squibb & Sons, Inc.
- 当前专利权人地址： NJ Princeton
- 主分类号： C07C59/11
- IPC分类号： C07C59/11 ; C07D309/30 ; C07F7/18
摘要：
Mevinic acid derivatives are provided which are 6-hydroxy-8-(2,2-dimethyl-1-oxybutoxy-2-methyl)-substituted-decahydronaphthalene esters and have the structure ##STR1## wherein Z is ##STR2## wherein R is alkali metal such as Na, or H or lower alkyl, and are HMG CoA reductase inhibitors and thus are useful as antihypercholesterolemic agents and in treating atherosclerosis, and also as antifungal agents.In addition, a method for preparing the above-mevinic acid derivatives is also provided.
公开/授权文献
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