发明授权
- 专利标题： Enzyme-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof
- 专利标题（中）： 酶抑制剂的尿素衍生物，其制备方法，包含它们的药剂及其用途
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申请号： US447414申请日： 1989-12-07
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公开(公告)号： US5116835A公开(公告)日： 1992-05-26
- 发明人: Wolfgang Ruger , Hansjorg Urbach , Dieter Ruppert , Bernward Scholkens
- 申请人： Wolfgang Ruger , Hansjorg Urbach , Dieter Ruppert , Bernward Scholkens
- 申请人地址： DEX Frankfurt am Main
- 专利权人： Hoechst Aktiengesellschaft
- 当前专利权人： Hoechst Aktiengesellschaft
- 当前专利权人地址： DEX Frankfurt am Main
- 优先权： DEX3841520 19881209
- 主分类号： C12N9/99
- IPC分类号： C12N9/99 ; A61K38/00 ; A61K38/55 ; A61P9/00 ; A61P9/12 ; A61P31/12 ; C07K1/02 ; C07K1/113 ; C07K5/06 ; C07K5/065 ; C07K14/81
摘要：
Enzyme-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof.The present invention relates to compounds of the formula I ##STR1## in which A and B denote, indpendently of one another, an amino acid,X as desired can be absent or represents --O--, --S--, --CF.sub.2 --, --CO-- or --CHR.sup.8,p and q denote, independently of one another, 0, 1, 2, 3 or 4, andR.sup.1 to R.sup.4 are defined in the description, as well as the salts thereof.The invention furthermore relates to a process for the preparation of the compounds of the formula I and to the use thereof as medicines.
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