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1902 条记录 (耗时 0.033 秒)

    SEEDED PRECIPITATION OF POLYPEPTIDES
    4.
    发明公开
    SEEDED PRECIPITATION OF POLYPEPTIDES 审中-公开

    公开(公告)号：US20240228531A9

    公开(公告)日：2024-07-11

    申请号：US18278519

    申请日：2022-02-22

    申请人： PreOmics GmbH

    发明人： Nils A. Kulak ,  Sebastian H. Johansson ,  Katrin Hartinger

    IPC分类号： C07K1/30 ,  C07K1/113

    CPC分类号： C07K1/30 ,  C07K1/1136

    摘要： The present invention relates to a method of processing or fractionating a sample comprising proteins, polypeptides and/or peptides, said method comprising (a) changing the physicochemical conditions of said sample; and (b) performing one or both of the following (i) and (ii): (i) adding solid particulate matter to said sample; and (ii) performing said method in a vessel with a rough surface; wherein steps (a) and (b) can be effected concomitantly or in any order; and wherein said processing or fractionating yields one or more first fractions of proteins, polypeptides and/or peptides as a precipitate on said particulate matter and/or said inhomogeneous surface, and a second fraction of proteins, polypeptides and/or peptides remaining in a supernatant.

    PREPARATION OF MAYTANSINOID ANTIBODY CONJUGATES BY A ONE-STEP PROCESS
    6.
    发明公开
    PREPARATION OF MAYTANSINOID ANTIBODY CONJUGATES BY A ONE-STEP PROCESS 审中-公开

    公开(公告)号：US20240156976A1

    公开(公告)日：2024-05-16

    申请号：US18352362

    申请日：2023-07-14

    申请人： ImmunoGen, Inc.

    发明人： Xinfang LI ,  Jared M. WORFUL

    IPC分类号： A61K47/68 ,  C07K1/113 ,  C07K16/28 ,  C07K16/32

    CPC分类号： A61K47/6803 ,  A61K47/6809 ,  A61K47/6819 ,  A61K47/6849 ,  A61K47/6867 ,  C07K1/113 ,  C07K16/2896 ,  C07K16/32

    摘要： The invention provides a one-step process for preparing a cell-binding agent cytotoxic agent conjugate comprising contacting a cell-binding agent with a cytotoxic agent to form a first mixture comprising the cell-binding agent and the cytotoxic agent and contacting the first mixture comprising the cell-binding agent and the cytotoxic agent with a bifunctional crosslinking reagent, which provides a linker, in a solution having a pH of about 4 to about 9 to provide a second mixture comprising the cell-binding agent cytotoxic agent conjugate, wherein the cell-binding agent is chemically coupled through the linker to the cytotoxic agent, free cytotoxic agent, and reaction by-products. The second mixture is then optionally subjected to purification to provide a purified cell-binding agent cytotoxic agent conjugate.

    PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF
    7.
    发明公开
    PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF 审中-公开

    公开(公告)号：US20240124525A1

    公开(公告)日：2024-04-18

    申请号：US18453118

    申请日：2023-08-21

    申请人： President and Fellows of Harvard College

    发明人： Gregory L. VERDINE ,  Kazuhiro HAYASHI

    IPC分类号： C07K7/56 ,  C07D207/16 ,  C07K1/113

    CPC分类号： C07K7/56 ,  C07D207/16 ,  C07K1/113

    摘要： The present invention provides a new type of alpha-helix nucleating cross-link (“staple”) formed by olefin metathesis of a proline derivative with an alkenyl side chain and another amino acid derivative with an alkenyl side chain. The proline derivatives as described herein have been found to be strong nucleators of alpha-helix formation. The invention also provides moieties for shielding the free amide N—H's at the N-terminus of an alpha-helix, thereby further stabilizing the helix. The proline derivatives, precursors prior to cross-linking, and the cross-linked peptides are provided as well as methods of using and preparing these compounds and peptides.