Disclosed is a thermoplastic resin composition which is improved in compatibility between polyphenylene ether and thermoplastic polyester and is excellent in processability, solvent resistance, and impact strength.This composition comprises:100 parts by weight of a composition comprising (A) 5-95% by weight of a polyphenylene ether and (B) 95-5% by weight of a thermoplastic polyester,(C) 0.5-100 parts by weight of an aromatic polycarbonate resin,(D) 0-50 parts by weight of a rubber-like polymer, and(E) 0.01-10 parts by weight of an amino resin obtained by modifying with an alcohol an addition reaction product of formaldehyde and at least one compound selected from the group consisting of melamine, guanamine and urea.