发明授权
- 专利标题: Aminopropanol derivatives, process for their preparation and pharmaceutical compositions comprising the same
- 专利标题(中): 氨基壬酸衍生物,其制备方法和包含其的药物组合物
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申请号: US572641申请日: 1991-08-27
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公开(公告)号: US5130487A公开(公告)日: 1992-07-14
- 发明人: Zoltan Budai , Tibor Mezei , Klara Reiter nee Esses , Eniko Sziri neKiszelly , Gizella Zsila , Gabor Gigler , Lujza Petocz , Maria Szecsey nee Hegedus , Marton Fekete , Valeria Hoffmann , Laszlo Kapolnai
- 申请人: Zoltan Budai , Tibor Mezei , Klara Reiter nee Esses , Eniko Sziri neKiszelly , Gizella Zsila , Gabor Gigler , Lujza Petocz , Maria Szecsey nee Hegedus , Marton Fekete , Valeria Hoffmann , Laszlo Kapolnai
- 申请人地址: HUX Budapest
- 专利权人: EGIS Gyogyszergyar
- 当前专利权人: EGIS Gyogyszergyar
- 当前专利权人地址: HUX Budapest
- 优先权: HUX4401 19890825
- 主分类号: A61K31/15
- IPC分类号: A61K31/15 ; A61K31/133 ; A61K31/357 ; A61K31/36 ; A61K31/40 ; A61K31/445 ; A61K31/452 ; A61K31/495 ; A61K31/55 ; A61P1/04 ; A61P9/06 ; A61P9/08 ; A61P9/10 ; A61P25/02 ; A61P25/04 ; A61P25/20 ; A61P29/00 ; C07C249/08 ; C07C249/12 ; C07C251/58 ; C07D213/16 ; C07D251/58 ; C07D295/08 ; C07D295/088 ; C07D317/56
摘要:
The invention relates to novel racemic or optically active aminopropanol derivatives of formula I ##STR1## wherein R and R.sup.1 are independently hydrogen atom, halogen atom, lower alkoxy, or together represent a methylene dioxy group,R.sup.2 and R.sup.3 together represent a chemical bond or independently stand for a hydrogen atom,R.sup.4 and R.sup.5 are independently hydrogen atom, C.sub.3-7 cycloalkyl group or straight or branched, saturated or unsaturated C.sub.1-12 alkyl group optionally substituted by one or more dialkylaminoalkyl, dimethoxyphenyl or phenyl groups, orR.sup.4 and R.sup.5 together with the adjacent nitrogen atom form a 4 to 7 membered ring optionally comprising an oxygen, sulfur or a further nitrogen atom, which ring is optionally substituted by a phenyl, benzyl or C.sub.1-3 alkyl group and the said substituents may carry a hydroxyl group, one or two methoxy groups, halogen atoms or trifluoromethyl groups, orR.sup.4 and R.sup.5 together with the adjacent nitrogen atom form a piperidine ring which is optionally substituted by a phenyl or benzyl group and, if desired, it comprises a double bond,R.sup.6 stands for hydrogen atom or benzoyl group, andn represents an integer from 3 to 6, acid-addition salts and quaternary ammonium derivatives thereof.Further the invention relates to processes for preparing these compounds.The compounds of the invention exert cardiac circulation controlling and/or improving, central nervous system tranquillizing and/or digestive system irregulations improving effects.
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