发明授权
US5132309A 2-oxo-3,8-diazaspiro(4,5)decane derivatives, pharmaceutical compositions
containing them and process for preparing same
失效
2-OXO-3,8-DIAZASPIRO（4,5）癸糖衍生物，含有它们的药物组合物及其制备方法
- 专利标题： 2-oxo-3,8-diazaspiro(4,5)decane derivatives, pharmaceutical compositions containing them and process for preparing same
- 专利标题（中）： 2-OXO-3,8-DIAZASPIRO（4,5）癸糖衍生物，含有它们的药物组合物及其制备方法
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申请号： US566279申请日： 1990-08-10
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公开(公告)号： US5132309A公开(公告)日： 1992-07-21
- 发明人: Edit Toth , Jozsef Torley , Sandor Gorog , Laszlo Szporny , Bela Kiss , Eva Palosi , Dora Groo , Istvan Laszlovszky , Erzsebet Lapis , Ferenc Auth , Laszlo Haal
- 申请人： Edit Toth , Jozsef Torley , Sandor Gorog , Laszlo Szporny , Bela Kiss , Eva Palosi , Dora Groo , Istvan Laszlovszky , Erzsebet Lapis , Ferenc Auth , Laszlo Haal
- 申请人地址： HUX Budapest
- 专利权人： Richter Gedeon Vegyeszeti Gyar RT
- 当前专利权人： Richter Gedeon Vegyeszeti Gyar RT
- 当前专利权人地址： HUX Budapest
- 优先权： HUX4094/89 19890810
- 主分类号： A61K31/42
- IPC分类号： A61K31/42 ; A61K31/445 ; A61P25/18 ; A61P25/20 ; A61P25/24 ; A61P25/26 ; A61P25/28 ; C07D211/22 ; C07D491/10 ; C07D491/113 ; C07D498/10
摘要：
The invention relates to, therapeutically active 2-oxo-3,8-diazaspiro[4,5]decane derivatives (I), ##STR1## wherein R means hydrogen, a C.sub.1-12 alkyl, C.sub.3-6 cycloalkyl, carbocyclic C.sub.6-10 aryl or carbocyclic C.sub.6-10 aryl-C.sub.1-4 alkyl group, the latter two optionally being substituted on their aromatic moiety by one or more, same or different halogen(s) or one or more C.sub.1-4 alkyl or C.sub.1-4 alkoxy group(s);one of R.sup.1 and R.sup.2 stands for a hydroxyl group whereas the other means a methyl gorup;R.sup.3 and R.sup.4, which are the same or different, represent hydrogen, one or more halogen(s), C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trihalomethyl group or a hydroxyl group optionally esterified by a C.sub.1-4 alkanoic acid; andn is 1 or 2,their isomers, solvates, hydrates, acid addition and quaternary ammonium salts.
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