发明授权
US5137914A Sulfonylamino substituted bicyclo [2.2.1]heptane hydroxamic acid
derivatives useful as pharmaceuticals
失效
磺酰胺取代双酚A（2.2.1）HEPTANE羟基酸衍生物有效用作药物
- 专利标题： Sulfonylamino substituted bicyclo [2.2.1]heptane hydroxamic acid derivatives useful as pharmaceuticals
- 专利标题（中）： 磺酰胺取代双酚A（2.2.1）HEPTANE羟基酸衍生物有效用作药物
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申请号： US668853申请日： 1991-03-15
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公开(公告)号： US5137914A公开(公告)日： 1992-08-11
- 发明人: Mitsuaki Ohtani , Takaharu Matsuura , Kazuhiro Shirahase
- 申请人： Mitsuaki Ohtani , Takaharu Matsuura , Kazuhiro Shirahase
- 申请人地址： JPX Osaka
- 专利权人： Shionogi & Co., Ltd.
- 当前专利权人： Shionogi & Co., Ltd.
- 当前专利权人地址： JPX Osaka
- 优先权： JPX2-103728 19900419
- 主分类号： A61K9/08
- IPC分类号： A61K9/08 ; A61K31/00 ; A61K31/18 ; A61K31/34 ; A61P7/00 ; A61P7/02 ; A61P9/00 ; A61P9/08 ; A61P9/10 ; A61P11/00 ; A61P11/08 ; A61P43/00 ; C07C311/10 ; C07C311/19 ; C07C311/20 ; C07C311/29 ; C07D493/08
摘要：
Sulfonylamino substituted bicyclyl hydroxamic acid derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 each is hydrogen or lower alkyl; R.sup.3 is hydrogen, lower alkyl, lower alkoxy, hydroxy or halogen; X is alkylene or alkenylene: Y is methylene or oxygen; and n is 0, 1, or 2, or the pharmaceutically acceptable salt thereof. These compounds have an advanced antagonistic activity to thromboxane A.sub.2 (TXA.sub.2)-receptor and are useful for the treatment of thrombosis, vasoconstriction, or bronchoconstriction, and the like disease which are induced by TXA.sub.2.
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