发明授权
US5143712A Method of determining a site of inflammation utilizing elam-1 ligands
失效
使用elam-1配体测定炎症部位的方法
- 专利标题: Method of determining a site of inflammation utilizing elam-1 ligands
- 专利标题(中): 使用elam-1配体测定炎症部位的方法
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申请号: US637868申请日: 1991-01-07
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公开(公告)号: US5143712A公开(公告)日: 1992-09-01
- 发明人: Brian K. Brandley , Michael Tiemeyer , Stuart J. Swiedler , Margaret Moreland , Hans Schweingruber
- 申请人: Brian K. Brandley , Michael Tiemeyer , Stuart J. Swiedler , Margaret Moreland , Hans Schweingruber
- 申请人地址: CA Alameda
- 专利权人: Glycomed Incorporated
- 当前专利权人: Glycomed Incorporated
- 当前专利权人地址: CA Alameda
- 主分类号: A61K31/70
- IPC分类号: A61K31/70 ; A61K51/08 ; C07H13/04 ; C07K14/705 ; G01N33/569
摘要:
Ligands in the form of N-acetyllactosamines which bind to endothelial leukocyte adhesion molecule-1 (ELAM-1) are disclosed. The ligand compounds can be formulated into pharmaceutical compositions and/or assay compositions used to alleviate inflammation and assay for the presence of (qualitative) and amount of (quantitative) ELAM-1 and thereby determine the presence, location and degree of inflammation. The ligands are encompassed by general structural formula I as follows: ##STR1## wherein one of A and B is hydrogen and one is an N-acetyl neuraminic acid residue; D and E are each independently hydrogen or a fucose residue; n is an integer of from 0 to 10 with the proviso that if n is 0, E is a fucose residue; F is hydrogen, a lactosylceramide residue or a linking group; and molecules equivalent to a compound of formula I regarding its ability to bind to an ELAM-1 receptor to the same degree as a compound of formula I.
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