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公开(公告)号：US20240002423A1
公开(公告)日：2024-01-04
申请号：US18463658
申请日：2023-09-08
申请人： INSTITUT PASTEUR , Institut national de recherche pour l’agriculture, l’alimentation et l’environnement , INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： Laurence MULARD , Guillaume LE HEIGET , Zhaohu HU , Louis-Antoine BAREL , Isabelle ANDRE , Claire MOULIS , Magali REMAUD-SIMEON , Sophie BARBE , Mounir BENKOULOUCHE , Akli BEN IMEDDOURENE
摘要： The present invention provides protected tetrasaccharides, their process of preparation and their use in the synthesis of oligosaccharides, in particular fragments of O-antigens from Shigella flexneri, for example of serotype 1a, 1b, 2a, 2b, 3a, X, 4a, 4b, 5a, 5b, 7a or 7b.
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公开(公告)号：US20230399352A1
公开(公告)日：2023-12-14
申请号：US18002467
申请日：2021-02-07
发明人： Zhengsong ZHANG , Zhenghua LI , Jingang ZHAO , Congyong ZHANG , Xuelian ZHENG , Yongfeng BU
摘要： A production apparatus and a production method of sucrose-6-ester are provided. The production apparatus includes a tank, a rotary distillation device, and a condensation device, the tank includes a separation chamber and a reaction chamber; the condensation device is sheathed inside the rotary distillation device, and the rotary distillation device is slidably connected in the separation chamber; a turntable of the rotary distillation device is fixed on a top surface of a drum, and a first heating device is provided on an outer wall of the turntable; the condensation device includes a condenser pipe, a water receiving plate, and a condensate water box that are connected sequentially from top to bottom; the condensation device is sheathed inside the drum of the rotary distillation device in a non-contact manner, and the condenser pipe is arranged to penetrate through the turntable and contacts a top surface of the tank.
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公开(公告)号：US11767340B2
公开(公告)日：2023-09-26
申请号：US17653819
申请日：2022-03-07
申请人： GLYCOM A/S
IPC分类号： C07H13/04 , A61K31/702 , A23L33/125 , A23L33/00 , C07H1/06
CPC分类号： C07H1/06 , A23L33/125 , A23L33/40 , A61K31/702 , C07H13/04 , A23V2002/00 , C07B2200/03
摘要： The invention relates to crystalline polymorphs of lacto-N-tetraose (LNT) and methods for making the same for use in pharmaceutical compositions, nutritional formulations and food supplements.
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4.发明申请公开(公告)号：US20230137160A1
公开(公告)日：2023-05-04
申请号：US17915690
申请日：2021-03-29
申请人： GALECTO BIOTECH AB
发明人： Ulf NILSSON , Jonathan CUMMINS
摘要： A process for preparing a compound of formula (X) The process includes reacting a compound of formula (IX) with an acetylating agent in the presence of a base in a suitable solvent and at a suitable temperature for a sufficient reaction time for preparing the compound of formula X. The process is suitable for large scale synthesis.
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5.发明授权公开(公告)号：US11634448B2
公开(公告)日：2023-04-25
申请号：US15624399
申请日：2017-06-15
发明人： Harald C. Ott , Xi Ren , Jordan P. Bloom , Taufiek Konrad Rajab
IPC分类号： A61K31/655 , C12N5/06 , C07H13/04 , A61L27/38 , A61L27/54 , C12N5/07 , A61K35/22 , A61K35/34 , A61K35/36 , A61K35/407 , A61K35/42 , A61K35/44 , A61L27/36
摘要： The present application provides methods of functionalizing an organ or tissue of a mammal by administering a nutrient (e.g., peracetylated N-azido galactosamine Ac4GalNAz) to the mammal or by culturing an organ or tissue in a bioreactor containing such nutrient. The present application also provides methods of selectively functionalizing extracellular matrix (ECM) of an organ or tissue of a mammal by administering a nutrient (e.g., peracetylated N-azido galactosamine Ac4GalNAz) to the mammal. In some aspects, the present application provides a decellularized scaffold of a mammalian organ or tissue comprising an extracellular matrix, wherein the extracellular matrix of the decellularized scaffold is functionalized with a chemical group that is reactive in a bioorthogonal chemical reaction, such as an azide chemical group. The present application also provides biological prosthetic mesh and mammalian organs and tissues for transplantation prepared according to the methods of the application.
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公开(公告)号：US11440931B2
公开(公告)日：2022-09-13
申请号：US16097166
申请日：2017-03-16
申请人： Jinan University
发明人： Xinsheng Yao , Yang Yu , Dan Zhang , Yang Ni , Xiuqi Bao , Lin Li , Caixía Zang , Hao Gao , Yuanpeng Zheng
IPC分类号： C07H13/06 , C07H1/08 , C07H13/04 , A61K31/7024
摘要： Provided are a series of crocins compounds and related pharmacological applications thereof in prevention and treatment of Alzheimer's disease. The series of crocins compounds are obtained by taking the Chinese herb, namely Gardenia jasminoides Ellis, as a raw material and separating same by means of various methods. The compounds playing a role in preventing oxidative injury caused by hydrogen peroxide (H2O2) and excitatory amino acid injury caused by L-glutamic acid are screened out by in-vitro cell experiments. The results show that the crocins compounds have good effect in preventing cell injury caused by H2O2 and L-glutamic acid. The compounds have good effect in preventing and treating Alzheimer's disease due to the fact that significant rise of oxidative stress and excitatory amino acid is a key factor for nerve injury in Alzheimer's disease, and have broad development and application prospect.
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公开(公告)号：US11267839B2
公开(公告)日：2022-03-08
申请号：US16913656
申请日：2020-06-26
申请人： GLYCOM A/S
IPC分类号： C07H1/06 , C07H13/04 , A61K31/702 , A23L33/125 , A23L33/00
摘要： The invention relates to crystalline polymorphs of lacto-N-tetraose (LNT) and methods for making the same for use in pharmaceutical compositions, nutritional formulations and food supplements.
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8.发明申请公开(公告)号：US20220056497A1
公开(公告)日：2022-02-24
申请号：US17354819
申请日：2021-06-22
申请人： Glycosyn LLC
摘要： The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
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9.发明授权公开(公告)号：US11230722B2
公开(公告)日：2022-01-25
申请号：US15914676
申请日：2018-03-07
申请人： Oxford University Innovation Limited , U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
摘要： Novel compounds and compositions containing (R)-3-hydroxybutyrate derivatives are disclosed. The compounds and compositions can be used as nutritional supplements to increase physical performance and as therapeutics to ameliorate symptoms of medical conditions, particularly neurological conditions, such as Alzheimer's and similar conditions. Novel methods for making R-3-hydroxybutyrate derivatives also are disclosed. Exemplary methods employ a supercritical solvent, such as supercritical carbon dioxide, and employ a lipase catalyzed esterification or transesterification reaction to produce the (R)-3-hydroxybutyrate derivatives.
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公开(公告)号：US20210269468A1
公开(公告)日：2021-09-02
申请号：US17127979
申请日：2020-12-18
摘要： Disclosed are UAP inhibitors to inhibit glucose flux in the hexosamine biosynthetic pathway and methods of treating a disease using the inhibitors.
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