发明授权
US5152998A Process for the isolation and purification of monosialoganglioside from
a starting lipidic mixture by complexation with alpha-cyclodextrin and
related intermediate compound
失效
通过与α-环糊精和相关中间体化合物络合从起始脂质混合物中分离和纯化单唾液酸神经节苷脂的方法
- 专利标题： Process for the isolation and purification of monosialoganglioside from a starting lipidic mixture by complexation with alpha-cyclodextrin and related intermediate compound
- 专利标题（中）： 通过与α-环糊精和相关中间体化合物络合从起始脂质混合物中分离和纯化单唾液酸神经节苷脂的方法
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申请号： US834454申请日： 1992-02-12
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公开(公告)号： US5152998A公开(公告)日： 1992-10-06
- 发明人: Benito Casu , Ennio Lanzarotti , Giangiacomo Torri , Annamaria Naggi , Armando Cedro
- 申请人： Benito Casu , Ennio Lanzarotti , Giangiacomo Torri , Annamaria Naggi , Armando Cedro
- 申请人地址： ITX Como
- 专利权人： Crinos Industria Farmacobiologica SpA
- 当前专利权人： Crinos Industria Farmacobiologica SpA
- 当前专利权人地址： ITX Como
- 优先权： ITX20942A/90 19900713
- 主分类号： C07H15/10
- IPC分类号： C07H15/10 ; C08B37/00
摘要：
By ultrafiltration of an aqueous solution wherein there have been formerly dissolved alfa-cyclodextrin and a raw lipidic mixture, the latter characterized in that it contains monosialoganglioside (GMl) either as the sole ganglioside or otherwise in a prevailing quantity over the other associated gangliosides, and after the removal of cyclodextrin at the end of the process, it is obtained GMl with a titer of at least 95%. The present invention concerns also the intermediate complex that it is being formed between the hereabove said monosialoganglioside and alfa-cyclodextrin.
公开/授权文献
- US6071116A Heat recovery apparatus and methods of use 公开/授权日：2000-06-06
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