公开(公告)号：US12091432B2

公开(公告)日：2024-09-17

申请号：US17677227

申请日：2022-02-22

Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.

Inventor： Lei Li ,  George Peng Wang ,  Madhusudhan Reddy Gadi ,  Jun Yin

IPC: C07H15/10

CPC classification number: C07H15/10

Abstract: The present disclosure is concerned with compounds, compositions, and methods for synthesizing sphingosines and glycolipids including glycosphingolipids, such as but not limited to lactosyl sphingosine.

公开(公告)号：US20240182940A1

公开(公告)日：2024-06-06

申请号：US17776729

申请日：2022-02-15

Applicant: LOCUS SOLUTIONS IPCO, LLC

Inventor： Lee SPEIGHT ,  Daniel HAGAMAN ,  Andrew MORRIS ,  Nicholas CALLOW ,  Tyler DIXON ,  Cherfan CHARBEL

IPC: C12P19/44 ,  A01N43/16 ,  A01P1/00 ,  A61L2/18 ,  A61L101/44 ,  C07H15/10 ,  C11D3/22 ,  C11D3/48

CPC classification number: C12P19/44 ,  A01N43/16 ,  A01P1/00 ,  A61L2/18 ,  C07H15/10 ,  C11D3/221 ,  C11D3/48 ,  A61L2101/44

Abstract: Novel sophorolipid derivatives with enhanced antimicrobial activity have been identified as disinfecting active ingredients. These derivatives are produced through a fermentation of Starmerella bombicola utilizing dextrose and an oleochemical feedstock that is high in oleic acid. A two-step synthetic scheme is used to generate a reactive aldehyde handle and then install nature-derived cationic biodegradable functional groups. These cationic sophorolipid derivatives are purified using ion exchange resins to afford high purity sophorolipid derivative salts for formulation into disinfecting consumer products.

公开(公告)号：US20240002423A1

公开(公告)日：2024-01-04

申请号：US18463658

申请日：2023-09-08

Applicant: INSTITUT PASTEUR ,  Institut national de recherche pour l’agriculture, l’alimentation et l’environnement ,  INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Laurence MULARD ,  Guillaume LE HEIGET ,  Zhaohu HU ,  Louis-Antoine BAREL ,  Isabelle ANDRE ,  Claire MOULIS ,  Magali REMAUD-SIMEON ,  Sophie BARBE ,  Mounir BENKOULOUCHE ,  Akli BEN IMEDDOURENE

IPC: C07H15/10 ,  C12P19/04 ,  C12P19/14 ,  C12P19/18 ,  C12P19/28 ,  C07H15/203 ,  C07H13/04

CPC classification number: C07H15/10 ,  C12P19/04 ,  C12P19/14 ,  C12P19/18 ,  C12P19/28 ,  C07H15/203 ,  C07H13/04

Abstract: The present invention provides protected tetrasaccharides, their process of preparation and their use in the synthesis of oligosaccharides, in particular fragments of O-antigens from Shigella flexneri, for example of serotype 1a, 1b, 2a, 2b, 3a, X, 4a, 4b, 5a, 5b, 7a or 7b.

公开(公告)号：US11845770B2

公开(公告)日：2023-12-19

申请号：US17971194

申请日：2022-10-21

Applicant: California Institute of Technology ,  Holoclara, Inc.

Inventor： Brian M. Stoltz ,  Corey M. Reeves ,  Eduardo J. Martinez ,  Simon Bailey

IPC: C07H15/18 ,  A61P29/00 ,  C07H15/04 ,  C07H15/10 ,  C07H15/26

CPC classification number: C07H15/18 ,  A61P29/00 ,  C07H15/04 ,  C07H15/10 ,  C07H15/26

Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. For example, the present invention provides methods of treating immune and/or inflammatory disorders by administering a composition comprising a compound having the structure of Formula (I).

公开(公告)号：US20220183291A1

公开(公告)日：2022-06-16

申请号：US17603021

申请日：2020-04-17

Applicant: BOYCE THOMPSON INSTITUTE FOR PLANT RESEARCH, INC.

Inventor： Murli MANOHAR ,  Frank SCHROEDER

IPC: A01N43/16 ,  C07H15/10

Abstract: Compositions and methods for protecting an organism from a pathogen are disclosed.

公开(公告)号：US20220010354A1

公开(公告)日：2022-01-13

申请号：US17485813

申请日：2021-09-27

Applicant: University of Washington through its Center for Commercialization ,  PerkinElmer Health Sciences, Inc.

Inventor： Alexander Cherkassky ,  Jason Cournoyer ,  Michael Gelb

IPC: C12Q1/34 ,  C07C233/18 ,  C07H15/10

Abstract: Provided are molecules and methods for detecting enzymatic activity of various lysosomal storage enzymes. The molecules may be used as internal standards that may be combined with substrates that have improved solubility.

公开(公告)号：US10975346B2

公开(公告)日：2021-04-13

申请号：US15041396

申请日：2016-02-11

Applicant: WAKAYAMA UNIVERSITY

Inventor： Masanori Yamaguchi

IPC: C12M1/40 ,  C07H15/26 ,  C12P19/26 ,  C07H13/04 ,  C07H15/10 ,  C07H17/02 ,  C12M1/00

Abstract: The present invention provides a novel sialo-sugar chain, a process for producing the sialo-sugar chain, and a device for producing the sialo-sugar chain. A sialo-sugar chain can be easily and efficiently mass-produced by reacting a sugar wherein a hydroxy groups is substituted with an alkynyl group (herein sometimes referred to as “alkynylated sugar”) with a specific sialic acid donor in the presence of a sialic acid-introducing enzyme.

公开(公告)号：US10858384B2

公开(公告)日：2020-12-08

申请号：US16571526

申请日：2019-09-16

Applicant: KODE BIOTECH LIMITED

Inventor： Nicolai Bovin ,  Lissa Gilliver ,  Stephen Henry ,  Elena Korchagina

IPC: C07H15/10 ,  C07H1/00 ,  C07H15/04 ,  C07F9/10 ,  C12N5/078 ,  C12N5/00 ,  C12N5/073 ,  A61K35/12

Abstract: Synthetic molecule construct of the structure F-S1-S2-L where F-S1 is an aminoalkylglycoside and S2-L is a dicarboxylated, e.g. adipylated, phosphatidylethanolamide are disclosed. The two terminal sugars of the aminoalkylglycoside (Galα1-3Galβ-) are the two terminal sugars of the Galili antigen.

公开(公告)号：US10479813B2

公开(公告)日：2019-11-19

申请号：US16251750

申请日：2019-01-18

Applicant: California Institute of Technology ,  Boyce Thompson Institute for Plant Research

Inventor： Andrea Choe ,  Paul W. Sternberg ,  Frank C. Schroeder ,  Stephan H. Von Reuss

IPC: A61K31/7028 ,  C07H15/04 ,  A01N37/36 ,  A01N63/02 ,  A61K31/454 ,  C07H15/08 ,  C07H15/10 ,  C07H15/18 ,  C07H15/26 ,  A01N43/16 ,  A01N43/38 ,  C07D309/10

Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.

公开(公告)号：US10414786B2

公开(公告)日：2019-09-17

申请号：US15804427

申请日：2017-11-06

Applicant: KODE BIOTECH LIMITED

Inventor： Nicolai Bovin ,  Lissa Gilliver ,  Stephen Henry ,  Elena Korchagina

IPC: C07H15/10 ,  C07H1/00 ,  C07H15/04 ,  C07F9/10 ,  C12N5/078 ,  C12N5/073 ,  C12N5/00 ,  A61K35/12

Abstract: A construct of the structure F—S1-S2 where: F—S1 is an aminoalkylglycoside where F is α-D-galactopyranosyl-(1→4)-β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside and S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl or 5-aminopentyl; S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is phosphatidylethanolamine.