发明授权
US5162505A Proteins modified with positively charged carriers and compositions
prepared therefrom
失效
用正电荷的载体和由其制备的组合物改性的蛋白质
- 专利标题: Proteins modified with positively charged carriers and compositions prepared therefrom
- 专利标题(中): 用正电荷的载体和由其制备的组合物改性的蛋白质
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申请号: US409150申请日: 1989-09-19
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公开(公告)号: US5162505A公开(公告)日: 1992-11-10
- 发明人: Richard T. Dean , Raymond H. Boutin , John Lister-James
- 申请人: Richard T. Dean , Raymond H. Boutin , John Lister-James
- 申请人地址: PA Malvern
- 专利权人: Centocor
- 当前专利权人: Centocor
- 当前专利权人地址: PA Malvern
- 主分类号: A61K51/10
- IPC分类号: A61K51/10 ; C07D207/44 ; C07D207/452 ; C07D207/46
摘要:
Protein conjugates comprising a protein covalently linked to at least one positively charged agent, so that the protein conjugate has an overall net positive charge in aqueous conditions at physiological pH are disclosed. The positively charged agents comprise polymers of three or more subunits selected from the group consisting of amino acids containing positively charged side chains and alkylamines. These protein conjugates have decreased blood clearance rates compared to conjugates which do not have the positively charged agents. The protein conjugates may further comprise diagnostic or therapeutic radionuclides bound to the protein or the positively charged agent through bifunctional coupling agents.
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