公开(公告)号：US20240294473A1

公开(公告)日：2024-09-05

申请号：US18568726

申请日：2022-06-09

Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

Inventor： Santosh Baburao MHASKE ,  Amol Basagonda VIVEKI ,  Mahesh Dattatraya POL

IPC: C07D207/444 ,  A61K31/341 ,  A61K31/4015 ,  C07D207/44 ,  C07D307/66

CPC classification number: C07D207/444 ,  A61K31/341 ,  A61K31/4015 ,  C07D207/44 ,  C07D307/66

Abstract: The present invention relates to functionalized Maleimides and Isomaleimides of general Formula (I) and a process for the preparation thereof, involving [3+2] annulation of α,β-unsaturated aldehydes with carbamoyl alkylates via an enolate pathway to afford highly functionalized compounds of Formula (I);

公开(公告)号：US10662153B2

公开(公告)日：2020-05-26

申请号：US16078254

申请日：2017-02-27

Applicant: The University of Toledo

Inventor： Terry D. Hinds, Jr. ,  David E. Stec ,  Christopher J. Trabbic

IPC: A61K31/4025 ,  A61K31/4015 ,  C07D403/02 ,  C07D207/44 ,  A61P3/04 ,  A61P3/10

Abstract: Thin molecules, compounds producible by cleaving bilirubin at its methylene site in the center of the molecule, methods of making the same, and methods of using the same, are described.

公开(公告)号：US10227351B2

公开(公告)日：2019-03-12

申请号：US15993669

申请日：2018-05-31

Applicant: VICTORIA LINK LIMITED

Inventor： Gary Brian Evans ,  Peter Michael Kelly ,  Peter Charles Tyler

IPC: C07D207/50 ,  C07D487/04 ,  C07D207/44 ,  C07D207/12 ,  C07D207/34 ,  C07C55/07 ,  C07C53/06 ,  C07C269/04 ,  A61K31/519 ,  A61P35/00 ,  A61P35/02

Abstract: The invention relates to salt forms of (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(methyl-thiomethyl)pyrrolidin-3-ol, as well as polymorphic forms of the salts. The invention further relates to processes for preparing the salt forms and to the use of the salt forms in the treatment of diseases and disorders where it is desirable to inhibit 5′-methylthioadenosine phosphorylase (MTAP).

公开(公告)号：US20190047952A1

公开(公告)日：2019-02-14

申请号：US16078254

申请日：2017-02-27

Applicant: The University of Toledo

Inventor： Terry D. Hinds, Jr. ,  David E. Stec ,  Christopher J. Trabbic

IPC: C07D207/44 ,  A61P3/04 ,  A61P3/10

CPC classification number: C07D207/44 ,  A61P3/04 ,  A61P3/10

Abstract: Thin molecules, compounds producible by cleaving bilirubin at its methylene site in the center of the molecule, methods of making the same, and methods of using the same, are described.

公开(公告)号：US20180237388A1

公开(公告)日：2018-08-23

申请号：US15750887

申请日：2016-08-01

Applicant: Conopco, Inc., a/b/a UNILEVER

Inventor： Andrew Martyn NORBURY ,  David William THORNTHWAITE

IPC: C07D201/08 ,  C07D207/38 ,  C07D207/44

CPC classification number: C07D201/08 ,  C07D207/38 ,  C07D207/44

Abstract: A process for the synthesis of lactams suitable for use in antimicrobial, anti-biofilm bacteriostatic compositions.

公开(公告)号：US20180220643A1

公开(公告)日：2018-08-09

申请号：US15750906

申请日：2016-07-28

Applicant: Conopco, Inc., d/b/a UNILEVER

Inventor： Paul Damien Price

IPC: A01N25/02 ,  C07D207/38 ,  C07D207/44 ,  A01N43/36

CPC classification number: A01N25/02 ,  A01N43/36 ,  A61K8/4913 ,  A61Q17/005 ,  C07D207/38 ,  C07D207/44 ,  A01N25/30

Abstract: Compositions comprising lactams and non-ionic surfactants, suitable for use as antimicrobial, anti-biofilm and bacteriostatic compositions.

公开(公告)号：US09994574B2

公开(公告)日：2018-06-12

申请号：US14441690

申请日：2013-11-12

Applicant: Victoria Link Limited

Inventor： Gary Brian Evans ,  Peter Michael Kelly ,  Peter Charles Tyler

IPC: C07D487/04 ,  A61K31/519 ,  C07C269/04 ,  C07D207/12 ,  C07D207/34 ,  C07C53/06 ,  C07C55/07 ,  C07D207/44 ,  A61P35/00

CPC classification number: C07D487/04 ,  C07B2200/13 ,  C07C53/06 ,  C07C55/07 ,  C07C269/04 ,  C07D207/12 ,  C07D207/34 ,  C07D207/44 ,  C07C271/22

Abstract: The invention relates to salt forms of (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(methyl-thiomethyl)pyrrolidin-3-ol, as well as polymorphic forms of the salts. The invention further relates to processes for preparing the salt forms and to the use of the salt forms in the treatment of diseases and disorders where it is desirable to inhibit 5′-methylthioadenosine phosphorylase (MTAP).

公开(公告)号：US08993785B2

公开(公告)日：2015-03-31

申请号：US14224700

申请日：2014-03-25

Applicant: David Hook ,  Thomas Ruch ,  Bernard Riss ,  Bernhard Wietfeld ,  Gottfried Sedelmeier ,  Matthias Napp ,  Markus Bänziger ,  Steven Hawker ,  Lech Ciszewski ,  Liladhar Murlidhar Waykole

Inventor： David Hook ,  Thomas Ruch ,  Bernard Riss ,  Bernhard Wietfeld ,  Gottfried Sedelmeier ,  Matthias Napp ,  Markus Bänziger ,  Steven Hawker ,  Lech Ciszewski ,  Liladhar Murlidhar Waykole

IPC: C07D207/38 ,  C07D207/267 ,  C07D207/44 ,  C07C269/04 ,  C07C227/16 ,  C07C227/22 ,  C07C227/32 ,  C07C229/34 ,  C07C231/02 ,  C07C233/47 ,  C07C271/22 ,  C07D207/24 ,  C07D207/26 ,  C07D207/27 ,  C07D207/273 ,  C07D207/277 ,  C07D207/40 ,  C07F7/10 ,  C07C219/18 ,  C07D207/12 ,  C07C227/20 ,  C07C231/12 ,  C07D207/404 ,  C07D403/06

CPC classification number: C07C231/02 ,  C07C219/18 ,  C07C227/16 ,  C07C227/20 ,  C07C227/22 ,  C07C227/32 ,  C07C229/34 ,  C07C231/12 ,  C07C231/14 ,  C07C233/47 ,  C07C269/04 ,  C07C271/22 ,  C07C2601/16 ,  C07D207/12 ,  C07D207/24 ,  C07D207/26 ,  C07D207/267 ,  C07D207/27 ,  C07D207/273 ,  C07D207/277 ,  C07D207/40 ,  C07D207/404 ,  C07D207/44 ,  C07D403/06 ,  C07F7/10 ,  Y02P20/55

Abstract: The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof, wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP-inhibitors, particularly in the preparation of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.

公开(公告)号：US08883050B2

公开(公告)日：2014-11-11

申请号：US13970750

申请日：2013-08-20

Applicant: FUJIFILM Corporation

Inventor： Yoshihiro Jimbo ,  Yutaro Norizuki ,  Yohei Ishiji ,  Kazunari Yagi

IPC: G02B5/23 ,  G02B1/04 ,  G03F7/105 ,  C07D207/44 ,  G03F7/027 ,  C09B55/00 ,  C09B69/10 ,  C07D401/04 ,  G03F7/00 ,  C07D417/04 ,  C09B57/10 ,  G03F1/00 ,  G03F7/033 ,  G02B5/22 ,  G03F7/032

CPC classification number: G02B1/04 ,  C07D207/44 ,  C07D401/04 ,  C07D417/04 ,  C09B55/009 ,  C09B57/10 ,  C09B69/109 ,  G02B5/223 ,  G03F7/0007 ,  G03F7/027 ,  G03F7/032 ,  G03F7/033 ,  G03F7/105

Abstract: Provided is a curable colored composition, transmitting the light in the magenta region and absorbing the light in the cyan region. A curable colored composition comprising a metal complex in which a compound represented by formula (I) below is coordinated to a metal atom or a metal compound.

Abstract translation: 提供可透过品红区域的光并吸收青色区域的光的可固化着色组合物。 一种可固化着色组合物，其包含其中由下式（I）表示的化合物与金属原子或金属化合物配位的金属络合物。

公开(公告)号：US08785490B2

公开(公告)日：2014-07-22

申请号：US13639864

申请日：2011-04-08

Applicant: John O. Trent ,  Jason B. Meier ,  Kelby B. Napier

Inventor： John O. Trent ,  Jason B. Meier ,  Kelby B. Napier

IPC: C07D209/42 ,  C07D207/44 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

CPC classification number: C07D403/12 ,  A61K31/132 ,  A61K31/335 ,  A61K31/4015 ,  A61K31/4045 ,  A61K31/41 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4196 ,  A61K31/454 ,  A61K31/47 ,  A61K31/472 ,  A61K31/473 ,  A61K31/4965 ,  A61K31/498 ,  A61K31/4985 ,  C07D217/24

Abstract: Some embodiments of this invention include methods for treating disease and methods for administering a compound of Formula (I). In some aspects of the invention, diseases can be treated by administration of compositions comprising a compound of Formula (I). Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I).

Abstract translation: 本发明的一些实施方案包括治疗疾病的方法和给予式（I）化合物的方法。 在本发明的一些方面，可以通过给予包含式（I）化合物的组合物来治疗疾病。 本发明一些实施方案的药物组合物包含式（I）的化合物。