发明授权
US5166171A 6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and
6-thiphenoxymethyl-4-hydroxytetrahydropyran-2-ones and the
corresponding dihydroxycarboxylic acid derivatives, salts and esters,
and in treating hypercholesterolemia
失效
6-苯氧基甲基-4-羟基四氢吡喃-2-酮和6-硫代氧甲基-4-羟基四氢吡喃-2-酮及相应的二羟基羧酸衍生物,盐和酯,以及治疗高胆固醇血症
- 专利标题: 6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiphenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, and in treating hypercholesterolemia
- 专利标题(中): 6-苯氧基甲基-4-羟基四氢吡喃-2-酮和6-硫代氧甲基-4-羟基四氢吡喃-2-酮及相应的二羟基羧酸衍生物,盐和酯,以及治疗高胆固醇血症
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申请号: US680613申请日: 1991-04-02
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公开(公告)号: US5166171A公开(公告)日: 1992-11-24
- 发明人: Heiner Jendralla , Gunther Wess , Wilhelm Bartmann , Gerhard Beck
- 申请人: Heiner Jendralla , Gunther Wess , Wilhelm Bartmann , Gerhard Beck
- 申请人地址: DEX Frankfurt am Main
- 专利权人: Hoechst Aktiengesellschaft
- 当前专利权人: Hoechst Aktiengesellschaft
- 当前专利权人地址: DEX Frankfurt am Main
- 优先权: DEX38-16-388 19880513; DEX38-19-999 19880611
- 主分类号: C07C59/68
- IPC分类号: C07C59/68 ; C07C323/09 ; C07D309/30
摘要:
6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, processes for the preparation of these compounds, their use as pharmaceuticals, pharmaceutical preparations and novel phenols and thiophenols Compounds of the general formula I ##STR1## and the corresponding open-chain dihydroxycarboxylic acids of the formula II ##STR2## in which X, Y and Z have the meanings given, and pharmacologically tolerated salts thereof with bases and pharmacologically tolerated esters thereof, processes for the preparation of these compounds, their use as pharmaceuticals and pharmaceutical preparations are described. Novel phenols and thiophenols of the formula III ##STR3## in which X, Y and Z have the meanings given, are also described.
公开/授权文献
- US5818115A Starting and charging apparatus 公开/授权日:1998-10-06
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