发明授权
- 专利标题: Preparation of glutaric acid derivatives
- 专利标题(中): 戊二酸衍生物的制备
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申请号: US504493申请日: 1990-04-04
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公开(公告)号: US5166406A公开(公告)日: 1992-11-24
- 发明人: Stephen Challenger
- 申请人: Stephen Challenger
- 申请人地址: NY New York
- 专利权人: Pfizer Inc.
- 当前专利权人: Pfizer Inc.
- 当前专利权人地址: NY New York
- 主分类号: C07C67/313
- IPC分类号: C07C67/313 ; C07C51/285 ; C07C67/333 ; C07C67/475 ; C07C69/34 ; C07C69/347 ; C07C69/42 ; C07C69/608 ; C07C69/74 ; C07C69/757 ; C07C205/42
摘要:
The invention provides a process for preparing a compound of the formula: ##STR1## or a base salt thereof, wherein R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl optionally substituted by up to 3 substituents each independently selected from the group consisting of C.sub.1 -C.sub.6 alkoxy and C.sub.1 -C.sub.6 alkoxy(C.sub.1 -C.sub.6 alkoxy)-; and R.sup.3 is C.sub.1 -C.sub.6 alkyl or benzyl, said benzyl group being optionally ring-substituted by up to 2 nitro or C.sub.1 -C.sub.4 alkoxy substituents comprising reacting a compound of the formula: ##STR2## wherein R.sup.1 is C.sub.1 -C.sub.4 alkyl, phenyl or benzyl or C.sub.1 -C.sub.4 alkoxy; and R.sup.2 and R.sup.3 are as previously defined for a compound of the formula (I), with hydrogen peroxide or a source of peroxide ions: said process being optionally followed by conversion of the compound of the formula (I) to a base salt thereof. The present invention also relates to novel compounds of the formula (II).