发明授权
- 专利标题： Method of hydroxylation with ATCC 55086
- 专利标题（中）： 用ATCC 55086进行羟基化的方法
-
申请号： US840601申请日： 1992-02-20
-
公开(公告)号： US5187074A公开(公告)日： 1993-02-16
- 发明人: Laszlo R. Treiber , Russell B. Lingham , Byron H. Arison , Lawrence F. Colwell, Jr. , Georgette Dezeny , Nancy E. Kohl
- 申请人： Laszlo R. Treiber , Russell B. Lingham , Byron H. Arison , Lawrence F. Colwell, Jr. , Georgette Dezeny , Nancy E. Kohl
- 申请人地址： NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： NJ Rahway
- 主分类号： C07D295/092
- IPC分类号： C07D295/092 ; C12P17/14
摘要：
A novel dipeptide isostere is the biotransformed product after incubation with a culture of Streptomyces. It inhibits HIV protease, and is useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as a compound, pharmaceutically acceptable salt, pharmaceutical composition ingredient, whether or not as a prodrug or as a combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
公开/授权文献
信息查询
