发明授权
- 专利标题： Benzimidazole derivatives, their preparation and use
- 专利标题（中）： 苯并咪唑衍生物，其制备和用途
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申请号： US731412申请日： 1991-07-17
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公开(公告)号： US5200422A公开(公告)日： 1993-04-06
- 发明人: Soren-Peter Olesen , Frank Watjen
- 申请人： Soren-Peter Olesen , Frank Watjen
- 申请人地址： DKX Glostrup
- 专利权人： NeuroSearch A/S
- 当前专利权人： NeuroSearch A/S
- 当前专利权人地址： DKX Glostrup
- 主分类号： C07D235/26
- IPC分类号： C07D235/26 ; C07D235/28 ; C07D235/30
摘要：
A compound having the formula ##STR1## wherein R.sup.1 is hydrogen, NH.sub.2 or C.sub.1-6 -alkyl which may be branched;X is O, S, NCN;Y is O, S;R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently of each other are hydrogen, halogen, CF.sub.3, NO.sub.2, NH.sub.2, OH, C.sub.1-6 -alkoxy, C(.dbd.O)-phenyl or SO.sub.2 NR.sup.I R.sup.II wherein R.sup.I and R.sup.II independently are hydrogen or C.sub.1-6 -alkyl;R.sup.11 is hydrogen, halogen, NO.sub.2 or SO.sub.2 NR'R" wherein R' and R" independently are hydrogen or C.sub.1-6 -alkyl;R.sup.13 is hydrogen, halogen, phenyl, CF.sub.3, NO.sub.2 ;R.sup.12 is hydrogen or together with R.sup.13 forms a C.sub.4-7 -carbocyclic ring which may be aromatic or partially saturated;R.sup.14 is hydrogen or together with R.sup.13 forms a C.sub.4-7 -carbocyclic ring which may be aromatic or partially saturated;pharmaceutical compositions thereof,and a method of treating a disease in a mammal, including a human, responsive to opening of potassium channels, which comprises administering to a mammal in need thereof an effective amount of a compound as first above indicated, are disclosed.
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