公开(公告)号：US12024509B2

公开(公告)日：2024-07-02

申请号：US16814328

申请日：2020-03-10

申请人： C4X Discovery Limited

发明人： Emma Louise Blaney ,  Barrie Phillip Martin ,  Thorsten Nowak ,  Martin John Watson

IPC分类号： C07D471/04 ,  A61K31/4192 ,  A61K31/435 ,  A61K31/4439 ,  A61K31/47 ,  A61P3/04 ,  A61P19/10 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P25/32 ,  A61P25/34 ,  A61P25/36 ,  A61P43/00 ,  C07C233/69 ,  C07C233/78 ,  C07C275/28 ,  C07C275/40 ,  C07D213/63 ,  C07D213/64 ,  C07D213/74 ,  C07D231/38 ,  C07D235/26 ,  C07D235/30 ,  C07D239/34 ,  C07D239/42 ,  C07D239/80 ,  C07D239/84 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

CPC分类号： C07D471/04 ,  C07C233/69 ,  C07C233/78 ,  C07C275/28 ,  C07C275/40 ,  C07D213/63 ,  C07D213/64 ,  C07D213/74 ,  C07D231/38 ,  C07D235/26 ,  C07D235/30 ,  C07D239/34 ,  C07D239/42 ,  C07D239/80 ,  C07D239/84 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： The present invention relates to compounds that are inhibitors of the orexin-1 receptor. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with orexin-1 receptor activity.

公开(公告)号：US20230180761A1

公开(公告)日：2023-06-15

申请号：US18166601

申请日：2023-02-09

申请人： CORTEVA AGRISCIENCE LLC

发明人： RONALD J. HEEMSTRA ,  RONALD ROSS, JR. ,  KYLE A. DEKORVER ,  KAITLYN GRAY ,  DANIEL I. KNUEPPEL ,  PETER VEDNOR ,  TIMOTHY P. MARTIN ,  JOSEPH D. ECKELBARGER ,  JOHN F. DAEUBLE, SR. ,  RICKY HUNTER ,  DAVID A. DEMETER ,  TONY K. TRULLINGER ,  ERICH W. BAUM ,  ZOLTAN L. BENKO ,  NAKYEN CHOY ,  GARY D. CROUSE ,  FANGZHENG LI ,  JEFFREY NISSEN ,  MONICA B. OLSON ,  MICHELLE RIENER ,  THOMAS C. SPARKS ,  FRANK J. WESSELS ,  MAURICE C. YAP

IPC分类号： A01N53/00 ,  C07C255/46 ,  C07C255/57 ,  C07C255/60 ,  C07C259/10 ,  C07D213/84 ,  C07D213/89 ,  C07D215/227 ,  C07C271/28 ,  C07C271/66 ,  C07D215/38 ,  C07D231/56 ,  C07D233/36 ,  C07C311/08 ,  C07C311/46 ,  C07D235/30 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07C331/12 ,  C07C381/10 ,  C07D205/04 ,  C07C237/42 ,  C07D207/452 ,  C07C255/29 ,  C07D209/49 ,  C07D213/75 ,  C07D213/81 ,  C07D309/14 ,  C07D231/12 ,  C07D331/04 ,  C07D333/36 ,  C07D249/08 ,  C07D207/10 ,  C07D285/06 ,  C07D295/32 ,  C07D305/08 ,  C07D207/273 ,  C07D233/80 ,  C07D261/12 ,  C07D263/26 ,  C07D277/36 ,  C07D307/33 ,  C07D333/48 ,  C07C237/22 ,  C07D213/56 ,  C07D277/30 ,  C07D307/52 ,  C07D333/60 ,  A01N37/22 ,  A01N37/34 ,  A01N41/10 ,  A01N43/40 ,  A01N43/60 ,  A01N43/653 ,  A01N43/707 ,  A01N43/82 ,  A01N43/90 ,  C07C233/63 ,  C07C233/65 ,  C07C317/14 ,  C07D241/20 ,  C07D253/07 ,  C07D487/04

CPC分类号： A01N53/00 ,  C07C255/46 ,  C07C255/57 ,  C07C255/60 ,  C07C259/10 ,  C07D213/84 ,  C07D213/89 ,  C07D215/227 ,  C07C271/28 ,  C07C271/66 ,  C07D215/38 ,  C07D231/56 ,  C07D233/36 ,  C07C311/08 ,  C07C311/46 ,  C07D235/30 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07C331/12 ,  C07C381/10 ,  C07D205/04 ,  C07C237/42 ,  C07D207/452 ,  C07C255/29 ,  C07D209/49 ,  C07D213/75 ,  C07D213/81 ,  C07D309/14 ,  C07D231/12 ,  C07D331/04 ,  C07D333/36 ,  C07D249/08 ,  C07D207/10 ,  C07D285/06 ,  C07D295/32 ,  C07D305/08 ,  C07D207/273 ,  C07D233/80 ,  C07D261/12 ,  C07D263/26 ,  C07D277/36 ,  C07D307/33 ,  C07D333/48 ,  C07C237/22 ,  C07D213/56 ,  C07D277/30 ,  C07D307/52 ,  C07D333/60 ,  A01N37/22 ,  A01N37/34 ,  A01N41/10 ,  A01N43/40 ,  A01N43/60 ,  A01N43/653 ,  A01N43/707 ,  A01N43/82 ,  A01N43/90 ,  C07C233/63 ,  C07C233/65 ,  C07C317/14 ,  C07D241/20 ,  C07D253/07 ,  C07D487/04 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14

摘要： This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

公开(公告)号：US20230122024A1

公开(公告)日：2023-04-20

申请号：US17971547

申请日：2022-10-21

申请人： Board of Regents, The University of Texas System

发明人： Jef De Brabander ,  Daniel Rosenbaum ,  Qiren Liang ,  Wentian Wang

IPC分类号： C07D491/107 ,  C07D235/30 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/06 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/428 ,  A61K31/4192 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/422 ,  A61K31/4355 ,  A61K31/4709 ,  A61K31/4184 ,  A61K31/501 ,  A61K31/506 ,  A61K31/423

摘要： Methods and compositions for agonizing a type-2 orexin receptor (OX2R) in a cell determined to be in need thereof, including the general method of (a) administering to a subject a cyclic guanidinyl OX2R agonist and (b) detecting a resultant enhanced wakefulness or increased resistance to diet-induced accumulation of body fat, or abbreviated recovery from general anesthesia or jet lag.

公开(公告)号：US20220402880A1

公开(公告)日：2022-12-22

申请号：US17753980

申请日：2020-09-23

申请人： Icahn School of Medicine At Mount Sinai

发明人： Nilesh ZAWARE ,  Ming-Ming ZHOU ,  Chunyan REN ,  Claudia KIM ,  Sudeh IZADMEHR ,  Matthew GALSKY

IPC分类号： C07D235/30 ,  C07D209/08 ,  C07D403/06 ,  A61P35/00

摘要： A genus of bicyclic inhibitors of CBX chromodomains is disclosed. The compounds are of the following genus: The compounds inhibit CBX proteins and, as a consequence, they are useful for treating prostate cancer, ovarian cancer, and B-cell lymphoma.

公开(公告)号：US11453647B2

公开(公告)日：2022-09-27

申请号：US16640490

申请日：2018-08-20

申请人： Merck Patent GmbH

发明人： Eva-Maria Tanzer ,  Kai Schiemann ,  Markus Klein

IPC分类号： C07D235/30 ,  A61P35/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D405/04 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D491/048 ,  C07D491/052 ,  C07D491/107 ,  C07D491/113 ,  C07D498/10 ,  A61K45/06

摘要： The invention relates to benzimidazole derivatives of the general formula I, and the use of the compounds of the present invention for the treatment and/or prevention of hyperproliferative or infectious diseases and disorders in mammals, especially humans, and pharmaceutical compositions containing such compound.

公开(公告)号：US20220169641A1

公开(公告)日：2022-06-02

申请号：US17399338

申请日：2021-08-11

申请人： vTv Therapeutics LLC

发明人： Adnan M.M. Mjalli ,  Dharma Rao Polisetti ,  Jareer Nabeel Kassis ,  Matthew J. Kostura ,  Mustafa Guzel ,  Otis Clinton Attucks ,  Robert Carl Andrews ,  Samuel Victory ,  Suparna Gupta

IPC分类号： C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  A61P1/16 ,  A61K31/4168 ,  A61K31/4188 ,  A61K31/428 ,  A61K31/437 ,  C07D235/30 ,  C07D513/04

摘要： Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating renal diseases are provided. The substituted fused imidazole derivatives may control the activity or the amount or both the activity and the amount of heme-oxygenase.

公开(公告)号：US20220000118A1

公开(公告)日：2022-01-06

申请号：US16492722

申请日：2018-03-08

申请人： NORTH CAROLINA STATE UNIVERSITY ,  AGILE SCIENCES, INC.

发明人： Christian Melander ,  David Kendall Jung ,  Samuel Onofre Reyes

IPC分类号： A01N47/30 ,  C07D233/88 ,  C07D405/12 ,  C07D409/12 ,  C07D401/12 ,  C07D235/30 ,  C07D403/12 ,  A61K31/4168 ,  A61K31/5377 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/4184 ,  A01P1/00 ,  A61P31/04 ,  A01N47/36 ,  A01N47/32 ,  C09D5/14 ,  A61L2/232

摘要： Provided are 2-aminoimidazole-phenyl derivative compounds of Formula (I): which compounds are useful in methods of controlling microbial growth, such as by enhancing the effects of an antibiotic administered in combination with the compound. Compositions including these compounds, devices including these compounds, and methods of using the same are also provided.

公开(公告)号：US11098018B2

公开(公告)日：2021-08-24

申请号：US16638590

申请日：2018-08-13

申请人： ACESION PHARMA ApS

发明人： Ulrik Svane Sørensen ,  Antonio Mete

IPC分类号： C07D235/30

摘要： A compound of the general formula (I). The compounds of formula I are useful for treatment of a cardiac disease, disorder or condition in a mammal.

公开(公告)号：US20210206728A1

公开(公告)日：2021-07-08

申请号：US17254890

申请日：2019-06-26

申请人： KPC PHARMACEUTICALS, INC.

发明人： Dahai WANG ,  Wenyuan QIAN ,  Shilan LIU ,  Shuhui CHEN

IPC分类号： C07D235/30

摘要： The present invention relates to benzimidazole compounds and an application thereof as IDH1 mutant inhibitors, in particular, to a compound as represented by formula (I), tautomers thereof, or pharmaceutically acceptable salts thereof.

公开(公告)号：US20210188804A1

公开(公告)日：2021-06-24

申请号：US16078128

申请日：2017-02-23

申请人： ACESION PHARMA ApS

发明人： Ulrik Svane SØRENSEN ,  Antonio METE

IPC分类号： C07D401/12 ,  C07D235/30 ,  C07D405/12 ,  C07D403/12 ,  C07D413/12 ,  C07D491/107 ,  C07D417/12

摘要： The present invention relates to a compound of the general formula (I). The compounds of formula I are useful for treatment of a cardiac disease, disorder or condition in a mammal.